Familiarity-Based Stimulus Generalization of Conditioned Suppression in Rats Is Dependent on the Perirhinal Cortex

被引：9

作者：

Robinson, Jasper ^{[1
]}

Whitt, Emma J. ^{[1
]}

Horsley, Rachel R. ^{[2
]}

Jones, Peter M. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England

[2] Nottingham Trent Univ, Sch Social Sci, Nottingham, England

来源：

BEHAVIORAL NEUROSCIENCE | 2010年 / 124卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

perirhinal cortex; familiarity; novelty; generalization; recognition memory; OBJECT-RECOGNITION; LATENT INHIBITION; HIPPOCAMPAL-FORMATION; EXCITOTOXIC LESIONS; DOUBLE DISSOCIATION; SPATIAL MEMORY; RHESUS-MONKEYS; RHINAL CORTEX; DISCRIMINATION; MODEL;

D O I：

10.1037/a0020900

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We report that bilateral. excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization After surgery. rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B) Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B Sham rats' generalization was greater when preexposure was to both A and 13 than when preexposure was to 13 only That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations

引用

页码：587 / 599

页数：13

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