user

Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase

被引：72
|
作者：
Hyun, MH [1 ]
Han, SC
Jin, JS
Lee, W
机构：
[1] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea
[2] Pusan Natl Univ, Chem Inst Funct Mat, Pusan 609735, South Korea
[3] Forea Food & Drug Adm, Dept Drug Evaluat, Eunpyung Ku, Seoul 122704, South Korea
[4] LG Chem Ltd, Taejon 305380, South Korea
来源：
CHROMATOGRAPHIA | 2000年 / 52卷 / 7-8期
关键词：
column liquid chromatography; enantiomer separation; chiral stationary phase; chiral crown ether; quinolone antibacterial agents;
D O I：
10.1007/BF02535722
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A chiral stationary phase derived from (+)-( 18-crown-6)-2,3,11,12-tetracarboxylic acid has been successfully used for the direct separation of the enantiomers of racemic fluoroquinolines containing a primary amino group being investigated as antibacterial agents. The chromatographic resolution behavior was found to depend on the content and the type of acidic and organic modifiers in the mobile phase and on the column temperature.
引用
收藏
页码：473 / 476
页数：4
相关论文
共 50 条
  • [1] Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase
    M. H. Hyun
    S. C. Han
    J. S. Jin
    W. Lee
    [J]. Chromatographia, 2000, 52 : 473 - 476
  • [2] Liquid chromatographic separation of the enantiomers of fluoroquinolone antibacterials on a chiral stationary phase based on a chiral crown ether
    Hyun, MH
    Han, SC
    [J]. JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 2002, 54 (1-3): : 235 - 243
  • [3] Liquid chromatographic enantiomer separation of racemic amine using chiral crown ether stationary phase
    Kim, BH
    Jung, J
    Han, YK
    [J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2006, 44 (01) : 27 - 31
  • [4] Enantioselective separation of racemic secondary amines on a chiral crown ether-based liquid chromatography stationary phase
    Steffeck, RJ
    Zelechonok, Y
    Gahm, KH
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2002, 947 (02) : 301 - 305
  • [5] Chiral resolution of diphenylalanine by high-performance liquid chromatography on a crown-ether-based chiral stationary phase and by NMR spectroscopy
    Lee, W
    Bang, E
    Lee, W
    [J]. CHROMATOGRAPHIA, 2003, 57 (7-8) : 457 - 461
  • [6] Chiral resolution of diphenylalanine by high-performance liquid chromatography on a crown-ether-based chiral stationary phase and by NMR spectroscopy
    W. Lee
    E. Bang
    W. Lee
    [J]. Chromatographia, 2003, 57 : 457 - 461
  • [7] IMPROVED CROWN ETHER-BASED CHIRAL STATIONARY PHASE
    SHINBO, T
    YAMAGUCHI, T
    YANAGISHITA, H
    KITAMOTO, D
    SAKAKI, K
    SUGIURA, M
    [J]. JOURNAL OF CHROMATOGRAPHY, 1992, 625 (02): : 101 - 108
  • [8] Liquid chromatographic resolution of racemic amino acids and their derivatives on a new chiral stationary phase based on crown ether
    Hyun, MH
    Jin, JS
    Lee, WJ
    [J]. JOURNAL OF CHROMATOGRAPHY A, 1998, 822 (01) : 155 - 161
  • [9] Separation mechanism of chiral stationary phase based on quinine and crown ether for the direct stereoselective separation of amino acids
    Wu Haixia
    Wang Dongqiang
    Zhao Jianchao
    Ke Yanxiong
    Liang Xinmiao
    [J]. CHINESE JOURNAL OF CHROMATOGRAPHY, 2016, 34 (01) : 62 - 67
  • [10] The effect of analyte lipophilicity on the resolution of α-amino acids on a HPLC chiral stationary phase based on crown ether
    Hyun, MH
    Jin, JS
    Han, SC
    Cho, YJ
    [J]. MICROCHEMICAL JOURNAL, 2001, 70 (03) : 205 - 209
12345