Unique allosteric mechanism regulating protein-protein interaction through phosphorylation: a case study of the conformational changes in the Syk tandem SH2 protein

被引：0
|
作者：
Hua, Duy P. [1 ]
Post, Carol Beth [1 ]
机构：
[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA
来源：
PROTEIN SCIENCE | 2016年 / 25卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：37 / 37
页数：1
相关论文
共 19 条
  • [1] Peptidomimetic Ligands for the Tandem SH2 Domain of the Syk Protein Involved in Signal Transduction
    Kuil, Joeri
    van Wandelen, Loek T. M.
    de Mol, Nico J.
    Liskamp, Rob M. J.
    PEPTIDES FOR YOUTH: THE PROCEEDINGS OF THE 20TH AMERICAN PEPTIDE SYMPOSIUM, 2009, 611 : 81 - 82
  • [2] Protein flexibility and ligand rigidity: A thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2
    de Mol, NJ
    Catalina, MI
    Dekker, FJ
    Fischer, MJE
    Heck, AJR
    Liskamp, RMJ
    CHEMBIOCHEM, 2005, 6 (12) : 2261 - 2270
  • [3] SH2 domains mediate the sequential phosphorylation of HS1 protein by p72(syk) and Src-related protein tyrosine kinases
    Ruzzene, M
    Brunati, AM
    Marin, O
    DonellaDeana, A
    Pinna, LA
    BIOCHEMISTRY, 1996, 35 (16) : 5327 - 5332
  • [4] A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein
    George, Roger
    Schuller, Annika C.
    Harris, Richard
    Ladbury, John E.
    JOURNAL OF MOLECULAR BIOLOGY, 2008, 377 (03) : 740 - 747
  • [5] Inter-domain Protein-Protein Interaction through a Unique α-Helix in the Hinge Region of E coli Topoisomerase I Leads to the Conformational Change of the Enzyme
    Dasgupta, Tumpa
    Tan, Kemin
    Tse-Dinh, Yuk-Ching
    FASEB JOURNAL, 2020, 34
  • [6] Sensitivity or specificity in protein interactions are independently regulated upon recognition: An SH2 case study
    Gerlach, Gabriella
    Camacho, Carlos J.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 203A - 203A
  • [7] Application of computer screening tools to investigate protein-protein interaction: Database mining studies on the tyrosine kinase p56-lck SH2 domain.
    Huang, N
    Chen, IJ
    Hayashi, J
    MacKerell, AD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U559 - U559
  • [8] Elucidating the suppressive mechanism of four inhibitors on VP39 and unique conformational changes with protein in mode 2
    Gao, Pengfei
    Luo, Song
    Liu, Jinxin
    Zhang, Enhao
    Duan, Lili
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2025, 334
  • [9] HCV core protein interaction with the STAT1 SH2 domain is associated with impairment of STAT1 phosphorylation and IFN signaling
    Lin, Wenyu
    Kim, Sun Suk
    Kamegaya, Yoshitaka
    Kim, Kyung Ah
    Holtzman, Michael J.
    Chung, Raymond T.
    HEPATOLOGY, 2006, 44 (04) : 297A - 297A
  • [10] Binding of the SARM LGD-4033 Induces Specific Conformational Changes in the AR-LBD and Exhibits a Unique Protein-Protein Interaction Profile Distinct from Steroidal Androgen Agonists and Other SARMs
    Marschke, K. B.
    van Oeveren, A.
    Hong, M. H.
    Sanders, J.
    Vajda, E. G.
    Zhi, L.
    ENDOCRINE REVIEWS, 2010, 31 (03) : S3 - S3
12