Synthesis and anticancer evaluation of certain α-methylene-γ-(4-substituted phenyl)-γ-butyrolactone bearing thymine, uracil, and 5-bromouracil

被引：18

作者：

Lee, KH

Huang, BR

Tzeng, CC ^{[1
]}

机构：

[1] Kaohsiung Med Coll, Sch Chem, Kaohsiung 807, Taiwan

[2] Tajen Jr Coll Pharm, Dept Pharm, Pingtung, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(98)00727-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Certain alpha-methylene-gamma-(4-substituted phenyl)-gamma-butyrolactone bearing thymine, uracil, and 5-bromouracil were synthesized and evaluated for their anticancer activity. These compounds demonstrated a strong growth inhibitory activity against leukemia cell lines. The anticancer potency for the substituents of the lactone C(gamma)-phenyl is in an order of 4-Ph > 4-Cl, 4-Br > 4-Me, 4-NO2 > 4-F. For the pyrimidine portion, 5-bromouracil is more potent than uracil and thymine. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：241 / 244

页数：4

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