Advances in aggregatable nanoparticles for tumor-targeted drug delivery

被引：109

作者：

Yu, Wenqi ^{[1
,2
]}

Shevtsov, Maxim ^{[4
]}

Chen, Xianchun ^{[3
]}

Gao, Huile ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Sichuan Engn Lab Plant Sourced Drug, Chengdu 610064, Peoples R China

[2] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610064, Peoples R China

[3] Sichuan Univ, Coll Mat Sci & Engn, Chengdu 610064, Peoples R China

[4] Russian Acad Sci RAS, Inst Cytol, St Petersburg 194064, Russia

来源：

CHINESE CHEMICAL LETTERS | 2020年 / 31卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Stimuli-responsive nanoparticles; Size aggregation; Tumor-targeted drug delivery; Transformation; Microenvironment modulation; GOLD NANOPARTICLES; CONDENSATION REACTION; PHOTODYNAMIC THERAPY; POLYMERIC MICELLES; CELLULAR UPTAKE; PARTICLE-SIZE; ACCUMULATION; RETENTION; NANOSTRUCTURES; BIODISTRIBUTION;

D O I：

10.1016/j.cclet.2020.02.036

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent days, aggregatable nanoparticles, which can specifically respond to certain stimulus, have shown great potential in tumor-targeted drug delivery with prolonged retention and deeper penetration. In this review, we summarize recent advances in design of aggregatable nanoparticles by different stimuli. Internal (pH and enzyme) and external (light, temperature and ROS) stimuli are introduced for a comprehensive description. Moreover, the aggregated nanoparticles usually exhibit photothermal, photoacoustic, PET and enhanced MRI contrast, which is also described. In the end, we discuss about the potential applications and challenges for the future clinical translation. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1366 / 1374

页数：9

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