A porous Cu(II)-based metal-organic framework carrier for pH-controlled anticancer drug delivery

被引：47
|
作者：
Liu, Weicong [1 ]
Zhong, Yuyu [1 ]
Wang, Xiaoxiong [2 ]
Zhuang, Canfeng [3 ]
Chen, Junhao [1 ]
Liu, Dong [4 ]
Xiao, Weiwei [5 ]
Pan, Ying [1 ]
Huang, Jianjing [1 ]
Liu, Jianqiang [1 ]
机构：
[1] Guangdong Med Univ, Sch Pharm, Key Lab Res & Dev New Med Mat, Guangdong Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China
[2] Shenzhen Polytech, Sch Civil & Environm Engn, Shenzhen 518055, Peoples R China
[3] Dongguan Matern & Child Healthcare Hosp, Dongguan 523000, Peoples R China
[4] Shenzhen Huachuang Biopharmaceut Technol Co Ltd, Shenzhen 518112, Peoples R China
[5] Southern Med Univ, Sch Publ Hlth, Biosafety Level Lab 3, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Guangdong, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2020年 / 111卷
关键词：
MOF; Drug carrier; MTT; IN-VITRO; CELLS; NANOPARTICLES; LIPOSOMES; PLATFORM; SYSTEM;
D O I：
10.1016/j.inoche.2019.107675
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new metal-organic framework with suitable channel size and good stability in biological buffer solution was investigated to load 5-fluorouracil (5-FU) though a simple adsorption process. The successful loading of 5-Fu was confirmed by the gas sorption measurement and the loading capacity was characterized by UV-Vis spectroscopy, which reveal a drug loading of 37.22%. The drug delivery in the simulated cancerous tissues (pH = 5.8 and 6.8) exhibited a more progressive release in comparison with that in the normal tissues (pH = 7.4), demonstrating a physiological pH-responsive drug release. Furthermore, as demonstrated by the MTT assay, this drug/MOF composite shows low cytotoxicity, good biocompatibility, and anticancer activity against cell lines A549 and HeLa. The result shows that 1 could be taken as a potential drug carrier.
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页数：6
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