The expression of Fcγ receptors in Hashimoto's thyroiditis

被引：10

作者：

Liu, Yalei ^{[1
]}

Liu, Mingming ^{[2
]}

Zhang, Yang ^{[1
]}

Qu, Chenxue ^{[3
]}

Lu, Guizhi ^{[1
]}

Huang, Youyuan ^{[1
]}

Zhang, Hong ^{[1
]}

Yu, Nan ^{[1
]}

Yuan, Shanshan ^{[1
]}

Gao, Ying ^{[1
]}

Gao, Yanming ^{[1
]}

Guo, Xiaohui ^{[1
]}

机构：

[1] Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China

[2] Chinese Acad Med Sci, Inst Microcirculat, Beijing 100005, Peoples R China

[3] Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2015年 / 294卷 / 01期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Hashimoto's thyroiditis; Fc gamma Rs; Fc gamma RIIB; B cells; MEMORY B-CELLS; RHEUMATOID-ARTHRITIS; IMMUNOGLOBULIN-G; FUNCTIONAL STATUS; LUPUS NEPHRITIS; DOWN-REGULATION; LYMPHOCYTES-B; AUTOANTIBODIES; ANTIBODY; DISEASE;

D O I：

10.1016/j.cellimm.2015.01.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The pathophysiological mechanism underlying Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) are diagnostic hallmarks of HT. These IgG antibodies regulate the balance of immunologic tolerance and autoimmunity via Fc gamma receptors (Fc gamma Rs). The aim of our study was to investigate the role of Fc gamma Rs in the pathogenesis of HT. The percentage of peripheral blood mononuclear cells (PBMCs) from HT patients bearing Fc gamma RII was significantly lower than that seen in healthy donors, and the mean fluorescence intensity (MFI) value of Fc gamma RII on PBMCs from HT patients was significantly higher. The percentage of PBMCs positive for Fc gamma RIII also was significantly higher in HT patients, and the percentage of B cells bearing Fc gamma RIIB in HT patients was significantly lower than that seen in healthy donors. Our study therefore provides evidence for Fc gamma Rs, especially Fc gamma RIIB, being involved in the pathogenesis of HT. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：33 / 38

页数：6

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