PROOF OF CONCEPT STUDY OF AN APOPTOSIS-SIGNAL REGULATING KINASE (ASK1) INHIBITOR (SELONSERTIB) IN COMBINATION WITH AN ACETYL-COA CARBOXYLASE INHIBITOR (GS-0976) OR A FARNESOID X RECEPTOR (FXR) AGONIST (GS-9674) IN NASH

被引：0

作者：

Lawitz, Eric ^{[1
]}

Herring, Robert ^{[2
]}

Younes, Ziad H. ^{[3
]}

Gane, Edward ^{[4
]}

Ruane, Peter J. ^{[5
]}

Aguilar, Raul ^{[6
]}

Jia, Catherine ^{[6
]}

Xu, Ren ^{[6
]}

McColgan, Bryan ^{[6
]}

Oberle, Corinna ^{[6
]}

Djedjos, C. Stephen ^{[6
]}

Subramanian, G. Mani ^{[6
]}

McHutchison, John G. ^{[6
]}

Myers, Robert P. ^{[6
]}

Middleton, Michael ^{[7
]}

Li, Kelvin ^{[8
]}

Hellerstein, Marc ^{[8
]}

Kwo, Paul ^{[9
]}

Noureddin, Mazen ^{[10
]}

Harrison, Stephen A. ^{[11
]}

机构：

[1] Univ Texas Hlth San Antonio, Texas Liver Inst, San Antonio, TX USA

[2] Qual Med Res, Nashville, TN USA

[3] GastroOne, Germantown, TN USA

[4] Auckland Clin Studies, Auckland, New Zealand

[5] Ruane Clin Res Grp, Los Angeles, CA USA

[6] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA

[7] Univ Calif San Diego, La Jolla, CA 92093 USA

[8] Univ Calif Berkeley, Berkeley, CA 94720 USA

[9] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA

[10] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[11] Pinnacle Clin Res, San Antonio, TX USA

来源：

SWISS MEDICAL WEEKLY | 2018年 / 148卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：24S / 24S

页数：1

共 4 条

[1] Proof of concept study of an apoptosis-signal regulating kinase (ASK1) inhibitor (selonsertib) in combination with an acetyl-CoA carboxylase inhibitor (GS-0976) or a farnesoid X receptor agonist (GS-9674) in NASH
Lawitz, E.
Herring, R., Jr.
Younes, Z. H.
Gane, E.
Ruane, P.
Schall, R. A.
Jia, C.
Xu, R.
Mccolgan, B.
Djedjos, S.
Subramanian, M.
Mchutchison, J. G.
Myers, R.
Middleton, M.
Li, K.
Hellerstein, M.
Kwo, P.
Noureddin, M.
Harrison, S.
JOURNAL OF HEPATOLOGY, 2018, 68 : S57 - S57
[2] PROOF OF CONCEPT STUDY OF AN APOPTOSIS-SIGNAL REGULATING KINASE (ASK-1) INHIBITOR (SELONSERTIB) IN COMBINATION WITH AN ACETYL-COA CARBOXYLASE INHIBITOR (GS-0976) OR A FARNESOID X RECEPTOR (FXR) AGONIST (GS-9674) IN NASH
Lawitz, Eric
Herring, Robert
Younes, Ziad H.
Gane, Edward
Ruane, Peter J.
Aguilar, Raul
Jia, Catherine
Xu, Ren
McColgan, Bryan J.
Natha, Macky
Djedjos, C. Stephen
Subramanian, Mani
McHutchison, John
Myers, Robert P.
Middleton, Michael S.
Li, Kelvin
Hellerstein, Marc
Kwo, Paul Yien
Noureddin, Mazen
Harrison, Stephen A.
GASTROENTEROLOGY, 2018, 154 (06) : S1166 - S1167
[3] Proof-of-concept study of an apoptosis-signal regulating kinase inhibitor (selonsertib) in combination with an acetyl-CoA carboxylase inhibitor (GS-0976) or a farnesoid X receptor agonist (GS-9674) in non-alcoholic steatohepatitis
Gane, E.
Lawitz, E.
Herring, R.
Younes, Z. H.
Ruane, P. J.
Aguilar, R.
Jia, C.
Xu, R.
Mccolgan, B.
Djedjos, S.
Subramanian, M.
Mchutchison, J. G.
Myers, R. P.
Middleton, M.
Li, K.
Hellerstein, M.
Kwo, P.
Noureddin, M.
Harrison, S. A.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 33 : 57 - 58
[4] GS-4997, an Inhibitor of Apoptosis Signal-Regulating Kinase (ASK1), Alone or in Combination with Simtuzumab for the Treatment of Nonalcoholic Steatohepatitis (NASH): A Randomized, Phase 2 Trial
Loomba, Rohit
Lawitz, Eric
Mantry, Parvez S.
Jaya-kumar, Saumya
Caldwell, Stephen H.
Arnold, Hays
Diehl, Anna Mae
Djedjos, Constantine S.
Jia, Catherine
Myers, Robert P.
Subramanian, Mani
McHutchison, John G.
Goodman, Zachary D.
Afdhal, Nezam H.
Charlton, Michael R.
HEPATOLOGY, 2016, 64 (06) : 1119A - 1120A

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