DNA repair of adriamycin induced damage in mouse and human cells differing in catalase activity

被引：1
|
作者：
Gruber, BM [1 ]
Anuszewska, EL [1 ]
机构：
[1] Drug Inst, Dept Vitamin Drugs, PL-00725 Warsaw, Poland
来源：
ACTA BIOCHIMICA POLONICA | 1998年 / 45卷 / 02期
关键词：
catalase; DNA repair; adriamycin;
D O I：
10.18388/abp.1998_4249
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Catalase is known to counteract cytotoxic effect of adriamycin, used as an anti-neoplastic drug. In cells with low catalase activity no repair of adriamycin induced lesions was observed up to 48 h post treatment. in cells with high catalase activity after 48 h the repair was either complete or partial depending on the human or mouse cell type used.
引用
收藏
页码：573 / 577
页数：5
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