Cloning and characterization of the murine P2XM receptor gene

被引：10
|
作者：
Nawa, G
Urano, T
Tokino, T
Ochi, T
Miyoshi, Y
机构：
[1] Osaka Univ, Sch Med, Dept Med Genet, Div Clin Genet, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Sch Med, Dept Orthoped Surg, Suita, Osaka 5650871, Japan
[3] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan
来源：
JOURNAL OF HUMAN GENETICS | 1998年 / 43卷 / 04期
关键词：
P2XM; murine; skeletal muscle; p53; RP-2;
D O I：
10.1007/s100380050086
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We have isolated the murine counterpart of the human P2XM gene (mP2XM), a P2X purinoceptor that is expressed predominantly in skeletal muscle. The mP2XM gene, consisting of 12 exons that span 10kb of genomic DNA, encodes a 379-amino-acid product with 83% identity to the human homologue. Two potential transmembrane domains (M1 and M2) are present in the predicted product, and a segment resembling the H5 region of voltage-gated ion channels is completely conserved between human and mouse P2XM proteins. Predominant expression of mP2XM in murine skeletal muscle was confirmed by Northern-blot analysis, and a low level of expression was detectable in lung tissue, although human lung does not express P2XM.
引用
收藏
页码：262 / 267
页数：6
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