Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea

被引：10
|
作者：
Kim, Min Chul [1 ]
Kim, Yong Sook [2 ,3 ]
Kang, Wan Seok [2 ]
Lee, Ki Hong [1 ]
Cho, Meeyoung [3 ]
Hong, Moon Hwa [3 ]
Lim, Kyung Seob [2 ]
Jeong, Myung Ho [1 ]
Ahn, Youngkeun [1 ,2 ]
机构：
[1] Chonnam Natl Univ Hosp, Dept Cardiol, 42 Jebong Ro, Gwangju 61469, South Korea
[2] Chonnam Natl Univ Hosp, Biomed Res Inst, Gwangju, South Korea
[3] Chonnam Natl Univ Hosp, Cell Regenerat Res Ctr, Gwangju, South Korea
来源：
JOURNAL OF KOREAN MEDICAL SCIENCE | 2017年 / 32卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
Mesenchymal Stem Cell Transplantation; Heart Failure; Myocardial Infarction; HEART-FAILURE; BONE-MARROW; ISCHEMIC CARDIOMYOPATHY; DISEASE;
D O I：
10.3346/jkms.2017.32.10.1708
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA (R) XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
引用
收藏
页码：1708 / 1712
页数：5
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