Decrease in Reduced-Form Albumin Among Chronic Kidney Disease Patients: New Insights in Cardiovascular Complications

被引：22

作者：

Terawaki, Hiroyuki ^{[1
]}

Era, Seiichi ^{[2
]}

Nakayama, Masaaki ^{[3
]}

Hosoya, Tatsuo ^{[1
]}

机构：

[1] Jikei Univ, Sch Med, Div Kidney & Hypertens, Kashiwa, Chiba 2778567, Japan

[2] Gifu Univ, Grad Sch Med, Div Physiol & Biophys, Gifu, Japan

[3] Tohoku Univ, Grad Sch Med, Res Div Dialysis & Chron Kidney Dis, Sendai, Miyagi 980, Japan

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2011年 / 15卷 / 02期

关键词：

Cardiovascular disease; Chronic kidney disease; Oxidative stress; Redox state of albumin; REDOX STATE; OXIDATIVE STRESS;

D O I：

10.1111/j.1744-9987.2010.00889.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

From the perspective of free cysteine residue (Cys-34), human serum albumin (HSA) comprises a mixture of human mercaptoalbumin (HMA), in which the Cys-34 is not oxidized, human non-mercaptoalbumin (HNA)-1, which has a disulfide bond that can be reversibly oxidized, mainly by cysteine, and HNA-2, which is strongly oxidized to form sulfinic (-SO2H) or sulfonic (-SO3H) species. We have developed a convenient high-performance liquid chromatographic (HPLC) system for the clear separation of HSA into HMA, HNA-1 and HNA-2, and we have studied the dynamic changes of HSA-redox under various states of chronic kidney disease, in both a clinical and an experimental setting. In this article, we discuss the relationship between HSA-redox (especially the decrease of the reduced form), dialyzable uremic toxins and incident cardiovascular disease based on our recent investigations.

引用

页码：156 / 160

页数：5

共 50 条

[1] Cardiovascular and renal complications among patients with chronic kidney disease (CKD) in the Netherlands
Overbeek, Jetty
de Jong, Hilda J.
Oudenhuijzen-Taanman, Martine
Pander, Jan
Penning-van Beest, Fernie J.
Oudenhuijzen, Martine
Vervloet, Marc
[J]. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2022, 31 : 413 - 413
[2] Chronic kidney disease and cardiovascular complications
Luca Di Lullo
Andrew House
Antonio Gorini
Alberto Santoboni
Domenico Russo
Claudio Ronco
[J]. Heart Failure Reviews, 2015, 20 : 259 - 272
[3] Chronic kidney disease and cardiovascular complications
Di Lullo, Luca
House, Andrew
Gorini, Antonio
Santoboni, Alberto
Russo, Domenico
Ronco, Claudio
[J]. HEART FAILURE REVIEWS, 2015, 20 (03) : 259 - 272
[4] Cardiovascular complications in chronic kidney disease
Sarnak, MJ
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 41 (06) : S11 - S17
[5] Cardiovascular complications of chronic kidney disease
Ross, Louise
Banerjee, Debasish
[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2013, 67 (01) : 4 - 5
[6] Cardiovascular complications in chronic kidney disease
Melk, A.
Schildhorn, C.
Kracht, D.
Wuehl, E.
[J]. MONATSSCHRIFT KINDERHEILKUNDE, 2013, 161 (11) : 1004 - 1010
[7] Cardiovascular Complications of Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease
Eller, K.
[J]. JOURNAL FUR MINERALSTOFFWECHSEL, 2014, 21 (01): : 10 - 13
[8] Vitamin K and cardiovascular complications in chronic kidney disease patients
Kaesler, Nadine
Schurgers, Leon J.
Floege, Jurgen
[J]. KIDNEY INTERNATIONAL, 2021, 100 (05) : 1023 - 1036
[9] New Insights into the Role of FGF-23 and Klotho in Cardiovascular Disease in Chronic Kidney Disease Patients
Memmos, Evangelos
Papagianni, Aikaterini
[J]. CURRENT VASCULAR PHARMACOLOGY, 2021, 19 (01) : 55 - 62
[10] Magnesium and cardiovascular complications of chronic kidney disease
Massy, Ziad A.
Drueeke, Tilman B.
[J]. NATURE REVIEWS NEPHROLOGY, 2015, 11 (07) : 432 - 442

← 1 2 3 4 5 →