Synthesis, crystal structures, biological activities and fluorescence studies of transition metal complexes with 3-carbaldehyde chromone thiosemicarbazone

被引：138
|
作者：
Li, Yong [1 ]
Yang, Zheng-Yin [1 ]
Wu, Jin-Cai [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 12期
基金：
中国国家自然科学基金;
关键词：
3-Carbaldehyde chromone thiosemicarbazone; Crystal structures; Fluorescence studies; DNA binding properties; Antioxidant activity; IN-VITRO; ANTIOXIDANT ACTIVITY; SCHIFF-BASES; DNA; BINDING; ANTIBACTERIAL; ANTIFUNGAL; COPPER(II); LIGANDS; RUTHENIUM(II);
D O I：
10.1016/j.ejmech.2010.09.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
3-Carbaldehyde chromone thiosemicarbazone (L) and its transition metal complexes were synthesized and characterized systematically. Crystal structures of Zn(11) and Ni(11) complexes were determined by single crystal X-ray diffraction analysis. Zn(II) complex exhibits blue fluorescence under UV light and its fluorescent property in solid state was investigated. Interactions of ligand and Cu(II), Zn(11) and Ni(11) complexes with DNA were investigated by spectral and viscosity studies, indicating the compounds bind to DNA via intercalation and Zn(II) complex binds to DNA most strongly. Antioxidant tests in vitro show the compounds possess significant antioxidant activity against superoxide and hydroxyl radicals, and the scavenging effects of Cu(11) complex are stronger than Zn(11), Ni(11) complexes and some standard antioxidants, such as mannitol and vitamin C. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：5692 / 5701
页数：10
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