1-Methoxypyrrole-2-carboxamide-A new pyrrole compound isolated from Streptomyces griseocarneus SWW368

被引：7

作者：

Wattanasuepsin, Watsapon ^{[1
,2
]}

Intra, Bungonsiri ^{[1
,2
]}

Euanorasetr, Jirayut ^{[3
]}

Watanabe, Yoshihiro ^{[4
]}

Mingma, Ratchanee ^{[5
]}

Fukasawa, Wataru ^{[4
]}

Mori, Mihoko ^{[4
,5
]}

Matsumoto, Atsuko ^{[4
,5
]}

Shiomi, Kazuro ^{[4
,5
]}

Panbangred, Watanalai ^{[1
,2
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Biotechnol, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Mahidol Univ Osaka Univ Collaborat Res Ctr Biosci, Bangkok, Thailand

[3] King Mongkuts Univ Technol Thonburi, Dept Microbiol, Fac Sci, Bangkok, Thailand

[4] Kitasato Univ, Grad Sch Infect Control Sci, Tokyo, Japan

[5] Kitasato Univ, Kitasato Inst Life Sci, Tokyo, Japan

来源：

JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY | 2017年 / 63卷 / 04期

关键词：

antibacterial; bioassay-guided fractionation; 1-methoxypyrrole-2-carboxamide; Streptomyces; NATURAL-PRODUCTS; SP NOV;

D O I：

10.2323/jgam.2016.10.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new pyrrole compound, 1-methoxypyrrole-2-carboxamide, was obtained from a culture broth of Streptomyces griseocarneus SWW368, which was isolated from the rhizospheric soil under a Para rubber tree (Hevea brasiliensis). The chemical structure was elucidated by 1D NMR, 2D NMR, and MS, as a pyrrole ring with a N-methoxy group and a primary amide group. It exhibited antibacterial properties against Kocuria rhizophila, Staphylococcus aureus and Xanthomonas campestris pv. oryzae; however, cytotoxicity of the compound at 714 mu M against several mammalian tumor cell lines, i.e. A549, PANC1, HT29, HT1299 and HeLa S3, were not detected.

引用

页码：207 / 211

页数：5

共 6 条

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[3] A new 2H-benzindazole compound from Alternaria alternata Shm-1, an endophytic fungus isolated from the fresh wild fruit of Phellinus igniarius
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