Copper-Catalyzed Azidative Multifunctionalization of Alkynes

被引：16

作者：

Zheng, Guangfan ^{[1
]}

Sun, Jiaqiong ^{[1
]}

Liu, Yang ^{[1
]}

Yang, Shengbiao ^{[1
]}

Li, Yan ^{[1
]}

Sun, Haizhu ^{[1
]}

Zhang, Qian ^{[1
]}

机构：

[1] Northeast Normal Univ, Dept Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Jilin, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 23期

关键词：

N-FLUOROBENZENESULFONIMIDE; ADENOSINE RECEPTORS; ALLYLIC AZIDES; REARRANGEMENT; CHEMISTRY; ACCESS; TRIFLUOROMETHYLAZIDATION; BENZODIAZEPINE; HYDROAZIDATION; HYDRAZINES;

D O I：

10.1021/acs.joc.7b02148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient copper-catalyzed azidative multifunctionalization of alkynes has been developed by using N-fluorobenzenesulfonimide (NFSI) as both nitrogen source and aryl source and trimethylsilyl azide (TMSN3) as azido source. This transformation proceeds under mild conditions, providing a series of alpha-azido-alpha-aryl imine in good yields by a single operation starting from a wide range of alkynes. The prepared alpha-azido-alpha-aryl imines could be easily converted into 1,5-piperizine-fused 1,2,3-triazoles and azido enamines.

引用

页码：12813 / 12820

页数：8

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