Imaging the pathology of Alzheimer's disease:: amyloid-imaging with positron emission tomography

被引：60
|
作者：
Klunk, WE
Engler, H
Nordberg, A
Bacskai, BJ
Wang, YM
Price, JC
Bergström, M
Hyman, BT
Långström, B
Mathis, CA
机构：
[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Lab Mol Neuropharmacol, Pittsburgh, PA 15213 USA
[2] Uppsala Univ, Positron Emiss Tomog Ctr, Uppsala Res Imaging Solut AB, Akad Sjukhuset, S-75185 Uppsala, Sweden
[3] Huddinge Univ Hosp, Karolinska Inst, Dept Geriatr Med, Neurotec Dept, S-14186 Stockholm, Sweden
[4] Massachusetts Gen Hosp, Alzheimers Res Unit, Dept Neurol, Charlestown, MA 02139 USA
[5] Univ Pittsburgh, Sch Med, Dept Radiol, Positron Emiss Tomog Facil, Pittsburgh, PA 15213 USA
来源：
NEUROIMAGING CLINICS OF NORTH AMERICA | 2003年 / 13卷 / 04期
关键词：
D O I：
10.1016/S1052-5149(03)00092-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The steep rise in the incidence of Alzheimer's disease (AD) has further added to the considerable public health burden caused by aging of the United States population. Among the most characteristic pathologic hallmarks of AD are neuritic plaques and neurofibrillary tangles. The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD.
引用
收藏
页码：781 / +
页数：10
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