Click chelators for platinum-based anticancer drugs

被引：95
|
作者：
Maisonial, Aurelie [3 ]
Serafin, Patrycja [3 ]
Traikia, Mounir [3 ]
Debiton, Eric [1 ,2 ]
Thery, Vincent [3 ]
Aitken, David J. [4 ]
Lemoine, Pascale [5 ,6 ]
Viossat, Bernard [5 ,6 ]
Gautier, Arnaud [3 ]
机构：
[1] Univ Clermont 1, INSERM, UMR 484, Lab Pharmacognosie Biotechnol,UFR Pharm, F-63005 Clermont Ferrand, France
[2] Ctr Jean Perrin, F-63005 Clermont Ferrand, France
[3] Univ Blaise Pascal, CNRS, UMR 6504, Lab SEESIB, F-63177 Clermont Ferrand, France
[4] Univ Paris 11, CNRS UMR 8182, Lab SOM ICMMO, F-91405 Orsay, France
[5] Univ Paris 05, Lab Cristallog, Fac Sci Pharmaceut & Biol, F-75270 Paris 06, France
[6] Univ Paris 05, CNRS, RMN Biol UMR 8015, Fac Sci Pharmaceut & Biol, F-75270 Paris 06, France
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2008年 / 02期
关键词：
click chemistry; platinum; chelates; cancer;
D O I：
10.1002/ejic.200700849
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Triazoles from "click chemistry" are convenient ligands for the formation of platinum complexes bearing combined triazole-amine or triazole-carboxylate moieties. Striking differences in the chelation modes are observed between the two series. One of the triazole-amine platinum complexes exhibits selective cytotoxicity against breast cancer cells lines. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
引用
收藏
页码：298 / 305
页数：8
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