Impregnation of Polymethyl Methacrylate with Carbamazepine in Supercritical Carbon Dioxide

被引:9
|
作者
Oparin, R. D. [1 ]
Belov, K., V [1 ]
Khodov, I. A. [1 ]
Dyshin, A. A. [1 ]
Kiselev, M. G. [1 ]
机构
[1] Russian Acad Sci, Krestov Inst Solut Chem, Ivanovo 153045, Russia
关键词
impregnation; polymethyl methacrylate; carbamazepine; supercritical CO2; POLY(METHYL METHACRYLATE); CO2; SPECTROSCOPY; SOLUBILITY; DISSOLUTION; KINETICS; DELIVERY; RELEASE; TRANSFORMATION; TRANSITION;
D O I
10.1134/S1990793121070101
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
Two polymethyl methacrylate (PMMA) samples are impregnated with carbamazepine (CBZ) in a supercritical CO2 (SC-CO2) medium at temperatures of 75 and 105 degrees C and a constant CO2 density of 1.3 of its critical value. Before that, to determine the kinetic parameters of CO2 sorption by the polymer matrix, high-pressure NMR spectroscopy is used. By Raman spectroscopy, it is established that both polymethyl methacrylate samples contain carbamazepine, whose concentration in the polymer is 2.7 times higher for the case of impregnation at 105 degrees C compared to that at 75 degrees C. In addition, it is shown that, in the process of impregnation, CBZ is not crystallized in the polymer matrix, but rather forms a solution in PMMA, which, in turn, agrees well with the results of the X-ray phase analysis. The difference in the conformations of CBZ molecules in the polymer matrices impregnated at two different temperatures is established.
引用
收藏
页码:1157 / 1165
页数:9
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