Grafting cyclodextrins to calcium phosphate ceramics for biomedical applications

被引：7

作者：

Jacobsen, Peter A. L. ^{[1
]}

Nielsen, Jeppe L. ^{[1
]}

Juhl, Maria V. ^{[2
]}

Theilgaard, Naseem ^{[2
]}

Larsen, Kim L. ^{[1
]}

机构：

[1] Aalborg Univ, Dept Biotechnol Chem & Environm Engn, DK-9000 Aalborg, Denmark

[2] Danish Technol Inst, Ctr Polymer Sci, DK-2630 Taastrup, Denmark

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2012年 / 72卷 / 1-2期

关键词：

Cyclodextrin; Hydroxyapatite; Grafting; Drug delivery; BETA-CYCLODEXTRIN; AQUEOUS-SOLUTION; DRUG-DELIVERY; IN-VIVO; HYDROXYAPATITE; SPECTROSCOPY; MONOLAYERS; IMPLANTS; RELEASE; POLYMER;

D O I：

10.1007/s10847-011-9958-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The grafting of hydroxyapatite/beta-tricalcium phosphate with beta-cyclodextrin was achieved using a two step reaction with (3-glycidyloxypropyl)trimethoxysilane as a linker. Firstly, the silane group was brought to react with the hydroxyl groups at the surface of the hydroxyapatite/beta-tricalcium phosphate and secondly, the epoxy group was brought to react with the beta-cyclodextrin. The amount and distribution of covalently bound beta-cyclodextrin were investigated by thermogravimetric analysis, colorimetric total sugar assay, fluorescence spectroscopy and confocal laser scanning microscopy. The concentration of grafted beta-cyclodextrin was found to be approximately 3.5 mu mol per gram of material corresponding to an almost complete surface coverage, when assuming a closed hexagonal packed monolayer.

引用

页码：173 / 181

页数：9

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