A Review on Drug Delivery System for Tumor Therapy

被引：58

作者：

Liu, Guoxiang ^{[1
]}

Yang, Lina ^{[1
]}

Chen, Guang ^{[1
]}

Xu, Fenghua ^{[1
]}

Yang, Fanghao ^{[1
]}

Yu, Huaxin ^{[1
]}

Li, Lingne ^{[1
]}

Dong, Xiaolei ^{[1
]}

Han, Jingjing ^{[1
]}

Cao, Can ^{[1
]}

Qi, Jingyu ^{[1
]}

Su, Junzhe ^{[1
]}

Xu, Xiaohui ^{[1
]}

Li, Xiaoxia ^{[1
]}

Li, Bing ^{[1
,2
]}

机构：

[1] Qingdao Univ, Basic Med Coll, Dept Genet & Cell Biol, Qingdao, Peoples R China

[2] Qingdao Univ, Dept Hematol, Affiliated Hosp, Qingdao, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

drug delivery system; delivery carriers; antitumor drug; targeting; tumor therapy; CARBOXYMETHYL CHITOSAN NANOPARTICLES; MODIFIED CATIONIC LIPOSOMES; GOLD NANOPARTICLES; TARGETED DELIVERY; GRAPHENE OXIDE; SIRNA DELIVERY; CO-DELIVERY; IN-VITRO; SILVER NANOPARTICLES; BSA NANOPARTICLES;

D O I：

10.3389/fphar.2021.735446

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, with the development of nanomaterials, the research of drug delivery systems has become a new field of cancer therapy. Compared with conventional antitumor drugs, drug delivery systems such as drug nanoparticles (NPs) are expected to have more advantages in antineoplastic effects, including easy preparation, high efficiency, low toxicity, especially active tumor-targeting ability. Drug delivery systems are usually composed of delivery carriers, antitumor drugs, and even target molecules. At present, there are few comprehensive reports on a summary of drug delivery systems applied for tumor therapy. This review introduces the preparation, characteristics, and applications of several common delivery carriers and expounds the antitumor mechanism of different antitumor drugs in delivery carriers in detail which provides a more theoretical basis for clinical application of personalized cancer nanomedicine in the future.</p>

引用

页数：22

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