The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity

被引：31
|
作者：
Eisenaecher, Katharina [1 ]
Steinberg, Christian [1 ]
Reindl, Wolfgang [1 ]
Krug, Anne [1 ]
机构：
[1] Tech Univ Munich, Dept Med 2, D-81675 Munich, Germany
来源：
IMMUNOBIOLOGY | 2007年 / 212卷 / 9-10期
关键词：
dendritic cells; toll-like receptors; RNA helicases; virus; type I interferon;
D O I：
10.1016/j.imbio.2007.09.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cells which are located at the interface of innate and adaptive immunity are targets for infection by many different DNA and RNA viruses. Dendritic cell subpopulations express specific nucleic acid recognition receptors belonging to the Toll-like receptor family (TLR3, 7, 8, 9) and the cytosolic RNA helicase family (RIG-1, MDA5, LGP2). Activation of dendritic cells by viral DNA and RNA via these receptors is essential for triggering the innate antiviral immune response and shaping the ensuing adaptive antiviral immunity. This review will summarize our current knowledge of viral nucleic acid recognition and signaling by Toll-like receptors and RNA helicases focusing on recent evidence for their specific functions in antiviral defense in vivo. (c) 2007 Elsevier GmbH. All rights reserved.
引用
收藏
页码：701 / 714
页数：14
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