Wnt signaling inhibits cementoblast differentiation

被引：0

作者：

Nemoto, Eiji ^{[1
]}

Koshikawa, Yohei ^{[1
]}

Kanaya, Sousuke ^{[1
]}

Tsuchiya, Masahiro ^{[2
]}

Tamura, Masato ^{[3
]}

Somerman, Martha J. ^{[4
]}

Shimauchi, Hidetoshi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Dent, Dept Periodontol & Endodontol, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Dept Aging & Geriatr Dent, Sendai, Miyagi 9808575, Japan

[3] Hokkaido Univ, Grad Sch Dent, Dept Biochem & Mol Biol, Sapporo, Hokkaido, Japan

[4] Univ Washington, Sch Dent, Dept Periodont, Seattle, WA USA

来源：

INTERFACE ORAL HEALTH SCIENCE 2009 | 2010年

关键词：

Wnt signaling; cementoblast; differentiation;

D O I：

10.1007/978-4-431-99644-6_16

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Writ signaling has been implicated in increased bone formation by controlling mesenchymal stem cell or osteoblastic cell functions; however the role of Wnt signaling on cementogenesis has not been examined. Exposure to Wnt3a inhibited the expression of the osteocalcin (OCN) gene. This effect was accompanied by decreased gene expression of Runx2. Pretreatment with Dickkopf-1 attenuated the suppressive effects of Wnt3a on mRNA expression of Runx2 and OCN on cementoblasts. These findings suggest that canonical Wnt signaling inhibits cementoblast differentiation via regulation of expression of Runx2. Elucidating the role of Wnt in controlling cementoblast function will provide new tools needed to improve on existing periodontal regeneration therapies.

引用

页码：113 / +

页数：2

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