Mixed drug intoxication involving zaleplon ("Sonata®")

被引：11
|
作者：
Moore, KA [1 ]
Zemrus, TL [1 ]
Ramcharitar, V [1 ]
Levine, B [1 ]
Fowler, DR [1 ]
机构：
[1] Off Chief Med Examiner State Maryland, Baltimore, MD 21201 USA
来源：
FORENSIC SCIENCE INTERNATIONAL | 2003年 / 134卷 / 2-3期
关键词：
zaleplon; suicide; fatality; forensic sciences; drug overdose;
D O I：
10.1016/S0379-0738(03)00130-0
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Zaleplon ("Sonata(R)") is a pyrazolopyrimidine derivative approved for use in the United States for the treatment of insomnia. To date, there has been little data in the toxicological literature where zaleplon has been implicated as causing a fatal intoxication, either alone or in combination with other drugs. This report documents a case where zaleplon was identified in a suicide by multiple drug ingestion. The following zaleplon concentrations were found: heart blood 2.2 mg/l; bile 8.6 mg/l and urine 1.4 mg/l. Zaleplon was also detected but not quantitated in the kidney and liver. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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页码：120 / 122
页数：3
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