Additive hazards regression with current status data

被引:148
|
作者
Lin, DY
Oakes, D
Ying, ZL
机构
[1] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[2] Univ Rochester, Med Ctr, Dept Biostat, Rochester, NY 14642 USA
[3] Rutgers State Univ, Dept Stat, Piscataway, NJ 08855 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
additive risk model; counting process; failure time; interval censoring; martingale; partial likelihood; proportional hazards; time-dependent covariate;
D O I
10.1093/biomet/85.2.289
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Current status data arise when the only knowledge about the failure time of interest is whether the failure occurs before or after a random monitoring time. We propose to analyse such data by the semiparametric additive hazards model, which specifies that the hazard function for the failure time associated with a set of possibly time-dependent covariates is the sum of an arbitrary baseline hazard function and a regression function of covariates. Under certain conditions on the monitoring time, one can make inferences about the regression parameters of the additive hazards model by using the familiar asymptotic theory and software for the proportional hazards model with right censored data. An application to a carcinogenicity experiment is provided.
引用
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页码:289 / 298
页数:10
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