Integrating Conductive Metal-Organic Framework with Graphene Oxide to Highly Sensitive Platform for Electrochemical Sensing

The rational selection and integration of materials play important roles in advancing electrochemical sensing. Herein, a highly sensitive electrochemical platform based on composites of graphene oxide (GO) and conductive YbHHTP metal-organic framework (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) for the detection of dopamine (DA) and uric acid (UA) is reported. The composites are prepared by the introduction of GO into the hydrothermal synthesis of YbHHTP. The morphology, structure, and property of the resultant GO/YbHHTP composites are characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, X-ray photoelectron spectroscopy, electrochemical impedance spectroscopy, and cycle voltammetry. The results show that this in situ integration strategy facilitates the homogeneous anchoring of YbHHTP nanorods on the surface of GO sheets to achieve a considerable conductivity in the composites and fast electrochemical kinetics for probe molecules. As a result, the GO(2.0)/YbHHTP-modified electrodes exhibit ultrahigh sensitivity in detection of DA (3.62 mu A mu M-1) and UA (1.97 mu A mu M-1) as well as excellent reproducibility, stability, and anti-interfere ability.