Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE

被引：28

作者：

Raimondo, Joseph V. ^{[1
]}

Heinemann, Uwe ^{[2
]}

de Curtis, Marco ^{[3
]}

Goodkin, Howard P. ^{[4
,5
]}

Dulla, Chris G. ^{[6
]}

Janigro, Damir ^{[7
,8
]}

Ikeda, Akio ^{[9
]}

Lin, Chou-Ching K. ^{[10
]}

Jiruska, Premysl ^{[11
]}

Galanopoulou, Aristea S. ^{[12
]}

Bernard, Christophe ^{[13
]}

机构：

[1] Univ Cape Town, Neurosci Inst, Dept Human Biol, Div Cell Biol, Cape Town, South Africa

[2] Charite Univ Med Berlin, Neurosci Res Ctr, Berlin, Germany

[3] Fdn Carlo Besta Neurol Inst, Epilepsy & Expt Neurophysiol Unit, Milan, Italy

[4] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[5] Univ Virginia, Dept Pediat, Charlottesville, VA USA

[6] Tufts Univ, Sch Med, Dept Neurosci, Boston, MA 02111 USA

[7] Flocel Inc, Cleveland, OH USA

[8] Case Western Reserve Univ, Cleveland, OH 44106 USA

[9] Kyoto Univ, Dept Epilepsy Movement Disorders & Physiol, Grad Sch Med, Sakyo Ku, Kyoto, Japan

[10] Natl Cheng Kung Univ, Coll Med & Hosp, Dept Neurol, Tainan, Taiwan

[11] Czech Acad Sci, Inst Physiol, Dept Dev Epileptol, Prague, Czech Republic

[12] Montefiore Med Ctr, Albert Einstein Coll Med, Saul R Korey Dept Neurol,Einstein Montefiore Epil, Lab Dev Epilepsy,Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA

[13] Aix Marseille Univ, INSERM, Inst Neurosci Syst, UMRS 1106, Marseille, France

来源：

EPILEPSIA | 2017年 / 58卷

关键词：

Brain slice preparation; Electrophysiological recording methods; Recording solution composition; In vitro models of seizures; Animal selection and killing; HIPPOCAMPAL SLICE CULTURES; LONG-TERM POTENTIATION; RAT-BRAIN-SLICES; CA1 PYRAMIDAL NEURONS; NETWORK ACTIVITY; PATCH-CLAMP; POSTICTAL REFRACTORINESS; SYNAPTIC-TRANSMISSION; PROTON MODULATION; GABA(A) RECEPTORS;

D O I：

10.1111/epi.13901

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous invitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.

引用

页码：40 / 52

页数：13

共 18 条

[1] Methodological standards and interpretation of video-electroencephalography in adult control rodents. A TASK1-WG1 report of the AES/ILAE Translational Task Force of the ILAE
Kadam, Shilpa D.
D'Ambrosio, Raimondo
Duveau, Venceslas
Roucard, Corinne
Garcia-Cairasco, Norberto
Ikeda, Akio
de Curtis, Marco
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EPILEPSIA, 2017, 58 : 10 - 27
[2] Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE
Hernan, Amanda E.
Schevon, Catherine A.
Worrell, Gregory A.
Galanopoulou, Aristea S.
Kahane, Philippe
de Curtis, Marco
Ikeda, Akio
Quilichini, Pascale
Williamson, Adam
Garcia-Cairasco, Norberto
Scott, Rod C.
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EPILEPSIA, 2017, 58 : 28 - 39
[3] Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE
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[4] Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE
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Ono, Tomonori
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Wagenaar, Joost
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EPILEPSIA, 2017, 58 : 53 - 67
[5] Revisiting the concept of drug-resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force
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EPILEPSIA, 2023, 64 (11) : 2891 - 2908
[6] A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE Task Force on Classification and Terminology
Engel, J
EPILEPSIA, 2001, 42 (06) : 796 - 803
[7] Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE
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EPILEPSIA OPEN, 2022,
[9] A proposed diagnostic scheme for people with epileptic seizures and with epilepsy. Report of the ILAE task force on classification and terminology
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AKTUELLE NEUROLOGIE, 2001, 28 (07) : 305 - +
[10] Epilepsy, seizures, physical exercise, and sports: A report from the ILAE Task Force on Sports and Epilepsy
Capovilla, Giuseppe
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