Injury in the era of genomics

被引:0
|
作者
Cobb, JP [1 ]
Brownstein, BH
Watson, MA
Shannon, WD
Laramie, JM
Qiu, YY
Stormo, GD
Morrissey, JJ
Buchman, TG
Karl, IE
Hotchkiss, RS
机构
[1] Washington Univ, Sch Med, Cellular Injury & Adaptat Lab, Injury Genom Grp,Dept Surg, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Cellular Injury & Adaptat Lab, Injury Genom Grp,Dept Genet, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Cellular Injury & Adaptat Lab, Injury Genom Grp,Dept Pathol & Immunol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Cellular Injury & Adaptat Lab, Injury Genom Grp,Dept Med, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Cellular Injury & Adaptat Lab, Injury Genom Grp,Dept Anesthesiol, St Louis, MO 63110 USA
来源
SHOCK | 2001年 / 15卷 / 03期
关键词
genetic; microarrays; sepsis; trauma; human;
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The traditional approach to the study of biology employs small-scale experimentation that results in the description of a molecular sequence of known function or relevance. In the era of the genome the reverse is true. as large-scale cloning and gene sequencing come first, followed by the use of computational methods to systematically determine gene function and regulation, The overarching goal of this new approach is to translate the knowledge learned from a systematic, global analysis of genomic data into a complete understanding of biology. For investigators who study shock, the specific goal is to increase understanding of the adaptive response to injury at the level of the entire genome. This review describes our initial experience using DNA microarrays to profile stress-induced changes in gene expression. We conclude that efforts to apply genomics to the study of injury are best coordinated by multi-disciplinary groups, because of the extensive expertise required.
引用
收藏
页码:165 / 170
页数:6
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