Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery

被引：40

作者：

Le, Tuan-Anh ^{[1
,2
]}

Zhang, Xingming ^{[3
]}

Hoshiar, Ali Kafash ^{[4
]}

Yoon, Jungwon ^{[1
,2
,5
]}

机构：

[1] Gyeongsang Natl Univ, Sch Mech & Aerosp Engn, Jinju 660701, South Korea

[2] Gyeongsang Natl Univ, ReCAPT, Jinju 660701, South Korea

[3] Harbin Inst Technol Weihai, Sch Naval Architecture & Ocean Engn, Weihai 264209, Peoples R China

[4] Islamic Azad Univ, Qazvin Branch, Fac Ind & Mech Engn, Qazvin 3419915195, Iran

[5] Gwangju Inst Sci & Technol, Sch Integrated Technol, 123 Cheomdan Gwagiro, Gwangju 61005, South Korea

来源：

SENSORS | 2017年 / 17卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

magnetic particle imaging; navigation resolution; magnetic nanoparticles; BLOOD-VESSELS; SYSTEM; NANOPARTICLES; PROPULSION; FIELDS;

D O I：

10.3390/s17092050

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Magnetic nanoparticles (MNPs) are effective drug carriers. By using electromagnetic actuated systems, MNPs can be controlled noninvasively in a vascular network for targeted drug delivery (TDD). Although drugs can reach their target location through capturing schemes of MNPs by permanent magnets, drugs delivered to non-target regions can affect healthy tissues and cause undesirable side effects. Real-time monitoring of MNPs can improve the targeting efficiency of TDD systems. In this paper, a two-dimensional (2D) real-time monitoring scheme has been developed for an MNP guidance system. Resovist particles 45 to 65 nm in diameter (5 nm core) can be monitored in real-time (update rate = 2 Hz) in 2D. The proposed 2D monitoring system allows dynamic tracking of MNPs during TDD and renders magnetic particle imaging-based navigation more feasible.

引用

页数：15

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