Studies on the synthesis and structure of N-(1-oxo-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane-4-carbonyl)-N'-aryl(alkyl)thioureas

Twenty-two carbonyl thioureas derivatives - N-(1-oxo-1-phospha-2,6,7-trioxabicyclo [2. 2. 2]octane-4-carbonyl)-N'-aryl(alkyl)thioureas 5a-5x were synthesized by the addition reaction oi 1-oxo-4-carbonyl isothiocyanate-2,6,7-trioxa-1-phosphabicyclo[2. 2, 2]octane 4 with various amines, The IR and H-1 NMR spectra of 5 show that most of them exist in the keto-thioketo form and only a few of them have keto-thioenol tautomer. IR and H-1 NMR data also indicate that compounds 5 have intramolecular hydrogen bond. The structures of 5 were also confirmed by elementary analysis and MS, The biological activities of 5 and the crystal structure of compound Sq are being tested.