Early Liver Transplantation for Severe Alcoholic Hepatitis

被引:8
|
作者
Mellinger, Jessica L. [1 ]
Stine, Jonathan G. [2 ,3 ,4 ,5 ]
机构
[1] Univ Michigan, Dept Med, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA
[2] Penn State Univ, Div Gastroenterol & Hepatol, Dept Med, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
[3] Penn State Univ, Dept Publ Hlth Sci, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
[4] Penn State Univ, Ctr Liver, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
[5] Penn State Univ, Inst Canc, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
关键词
Alcohol use disorder; Cirrhosis; Alcohol-related liver disease; Relapse; MORTALITY; DISEASE; PATTERNS;
D O I
10.1007/s10620-020-06159-9
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Although alcohol-associated liver disease has long been a major component of the liver disease landscape, it was overshadowed by chronic hepatitis C until recently. Nevertheless, with the declining incidence of hepatitis C in the wake of highly effective antiviral therapy, attention has shifted to the increasing burden of alcohol-associated liver disease. The incidence of advanced alcohol-associated liver disease, including acute alcoholic hepatitis and alcohol-associated cirrhosis, is rising in parallel with increasing rates of alcohol use disorders. As a result, alcohol-associated liver disease is now one of the most common indications for liver transplantation. Rates of liver transplantation for acute acute alcoholic hepatitis are rising as well in spite of the sparse guidance regarding candidate selection, counseling, postoperative care, long-term follow-up, and other best practices. To this day, liver transplant for acute alcoholic hepatitis remains a hotly debated clinical controversy.
引用
收藏
页码:1608 / 1614
页数:7
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