Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants

被引：153

作者：

Nan, Hongmei ^{[1
,2
]}

Hutter, Carolyn M. ^{[3
]}

Lin, Yi ^{[4
]}

Jacobs, Eric J. ^{[5
]}

Ulrich, Cornelia M. ^{[4
,6
]}

White, Emily ^{[4
,7
]}

Baron, John A. ^{[8
]}

Berndt, Sonja I. ^{[9
]}

Brenner, Hermann ^{[10
,11
]}

Butterbach, Katja ^{[10
]}

Caan, Bette J. ^{[12
]}

Campbell, Peter T. ^{[5
]}

Carlson, Christopher S. ^{[4
]}

Casey, Graham ^{[13
]}

Chang-Claude, Jenny ^{[14
]}

Chanock, Stephen J. ^{[9
]}

Cotterchio, Michelle ^{[15
]}

Duggan, David ^{[16
]}

Figueiredo, Jane C. ^{[13
]}

Fuchs, Charles S. ^{[17
]}

Giovannucci, Edward L. ^{[18
]}

Gong, Jian ^{[4
]}

Haile, Robert W. ^{[13
]}

Harrison, Tabitha A. ^{[4
]}

Hayes, Richard B. ^{[19
]}

Hoffmeister, Michael ^{[10
]}

Hopper, John L. ^{[20
]}

Hudson, Thomas J. ^{[21
,22
]}

Jenkins, Mark A. ^{[20
]}

Jiao, Shuo ^{[4
]}

Lindor, Noralane M. ^{[23
]}

Lemire, Mathieu ^{[22
]}

Le Marchand, Loic ^{[24
]}

Newcomb, Polly A. ^{[4
]}

Ogino, Shuji ^{[17
,25
,26
]}

Pflugeisen, Bethann M. ^{[4
]}

Potter, John D. ^{[4
,27
]}

Qu, Conghui ^{[4
]}

Rosse, Stephanie A. ^{[4
]}

Rudolph, Anja ^{[14
]}

Schoen, Robert E. ^{[28
]}

Schumacher, Fredrick R. ^{[13
]}

Seminara, Daniela ^{[3
]}

Slattery, Martha L. ^{[29
]}

Thibodeau, Stephen N. ^{[30
,31
]}

Thomas, Fridtjof ^{[32
]}

Thornquist, Mark ^{[4
]}

Warnick, Greg S. ^{[4
]}

Zanke, Brent W. ^{[33
]}

Gauderman, W. James ^{[13
]}

机构：

[1] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46204 USA

[2] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA

[3] NHGRI, NIH, Bethesda, MD 20892 USA

[4] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[5] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[6] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA

[7] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

[8] Univ N Carolina, Sch Med, Div Gastroenterol & Hepatol, Chapel Hill, NC USA

[9] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[10] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[11] German Canc Consortium DKTK, Heidelberg, Germany

[12] Kaiser Permanente Med Care Program No Calif, Div Res, Oakland, CA USA

[13] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[14] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[15] Canc Care Ontario, Prevent & Canc Control, Toronto, ON, Canada

[16] Translat Genom Res Inst TGen, Genet Basis Human Dis Div, Phoenix, AZ USA

[17] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[18] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Channing Div Network Med, Boston, MA 02115 USA

[19] NYU, Sch Med, Dept Populat Hlth, Div Epidemiol, New York, NY USA

[20] Univ Melbourne, Melbourne Sch Populat Hlth, Melbourne, Vic 3010, Australia

[21] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[22] Ontario Inst Canc Res, Toronto, ON, Canada

[23] Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ USA

[24] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96822 USA

[25] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[26] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[27] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand

[28] Univ Pittsburgh, Med Ctr, Dept Med & Epidemiol, Pittsburgh, PA USA

[29] Univ Utah, Hlth Sci Ctr, Dept Internal Med, Salt Lake City, UT USA

[30] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[31] Mayo Clin, Dept Med Genet, Rochester, MN USA

[32] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Div Biostat & Epidemiol, Memphis, TN 38163 USA

[33] Ottawa Hosp, Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada

[34] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[35] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA

[36] Harvard Univ, Sch Med, Boston, MA USA

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2015年 / 313卷 / 11期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN E-2 BIOSYNTHESIS; COLON-CANCER; PIK3CA MUTATION; METAANALYSIS; CYCLOOXYGENASE-2; CHEMOPREVENTION; INTERLEUKIN-16; POLYMORPHISMS;

D O I：

10.1001/jama.2015.1815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene x environment interactions between regular use of aspirin and/or NSAIDs and single-nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS Case-control study using data from 5 case-control and 5 cohort studies initiated between 1976 and 2003 across the United States, Canada, Australia, and Germany and including colorectal cancer cases (n=8634) and matched controls (n=8553) ascertained between 1976 and 2011. Participants were all of European descent. EXPOSURES Genome-wide SNP data and information on regular use of aspirin and/or NSAIDs and other risk factors. MAIN OUTCOMES AND MEASURES Colorectal cancer. RESULTS Regular use of aspirin and/or NSAIDs was associated with lower risk of colorectal cancer (prevalence, 28% vs 38%; odds ratio [OR], 0.69 [95% Cl, 0.64-0.74]; P = 6.2 x 10(-28)) compared with nonregular use. In the conventional logistic regression analysis, the SNP rs2965667 at chromosome 12p12.3 near the MGST1 gene showed a genome-wide significant interaction with aspirin and/or NSAID use (P = 4.6 x 10(-9) for interaction). Aspirin and/or NSAID use was associated with a lower risk of colorectal cancer among individuals with rs2965667-TT genotype (prevalence, 28% vs 38%; OR, 0.66 [95% CI, 0.61-0.70]; P =7.7 x 10(-33)) but with a higher risk among those with rare (4%) TA or AA genotypes (prevalence, 35% vs 29%; OR, 1.89 [95% Cl, 1.27-2.81]; P = .002). In case-only interaction analysis, the SNP rs16973225 at chromosome 15q25.2 near the IL16 gene showed a genome-wide significant interaction with use of aspirin and/or NSAIDs (P = 8.2 x 10(-9) for interaction). Regular use was associated with a lower risk of colorectal cancer among individuals with rs16973225-AA genotype (prevalence, 28% vs 38%; OR, 0.66 [95% CI, 0.62-0.71]; P = 1.9 x 10(-30)) but was not associated with risk of colorectal cancer among those with less common (9%) AC or CC genotypes (prevalence, 36% vs 39%; OR, 0.97 [95% Cl, 0.78-1.20]; P = .76). CONCLUSIONS AND RELEVANCE In this genome-wide investigation of gene x environment interactions, use of aspirin and/or NSAIDs was associated with lower risk of colorectal cancer, and this association differed according to genetic variation at 2 SNPs at chromosomes 12 and 15. Validation of these findings in additional populations may facilitate targeted colorectal cancer prevention strategies.

引用

页码：1133 / 1142

页数：10

共 50 条

[1] Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility
Hurwitz, Lauren M.
Webb, Penelope M.
Jordan, Susan J.
Doherty, Jennifer A.
Harris, Holly R.
Goodman, Marc T.
Shvetsov, Yurii B.
Modugno, Francesmary
Moysich, Kirsten B.
Schildkraut, Joellen M.
Berchuck, Andrew
Anton-Culver, Hoda
Ziogas, Argyrios
Menon, Usha
Ramus, Susan J.
Wu, Anna H.
Pearce, Celeste Leigh
Wentzensen, Nicolas
Tworoger, Shelley S.
Pharoah, Paul D. P.
Trabert, Britton
[J]. JAMA NETWORK OPEN, 2023, 6 (02) : E230666
[2] Aspirin Use and Incidence of Colorectal Cancer According to Lifestyle Risk
Sikavi, Daniel R.
Wang, Kai
Ma, Wenjie
Drew, David A.
Ogino, Shuji
Giovannucci, Edward L.
Cao, Yin
Song, Mingyang
Nguyen, Long H.
Chan, Andrew T.
[J]. JAMA ONCOLOGY, 2024,
[3] Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status
Nishihara, Reiko
Lochhead, Paul
Kuchiba, Aya
Jung, Seungyoun
Yamauchi, Mai
Liao, Xiaoyun
Imamura, Yu
Qian, Zhi Rong
Morikawa, Teppei
Wang, Molin
Spiegelman, Donna
Cho, Eunyoung
Giovannucci, Edward
Fuchs, Charles S.
Chan, Andrew T.
Ogino, Shuji
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (24): : 2563 - 2571
[4] Aspirin Use and Risk of Colorectal Cancer According to Tumor Immunity Status
Cao, Yin
Nishihara, Reiko
Qian, Zhi Rong
Song, Mingyang
Mima, Kosuke
Inamura, Kentaro
Nowak, Jonathan
Drew, David
Lochhead, Paul
Nosho, Katsuhiko
Morikawa, Teppei
Zhang, Xuehong
Wu, Kana
Wang, Molin
Garrett, Wendy
Giovannucci, Edward
Fuchs, Charles
Ogino, Shuji
Chan, Andrew T.
[J]. GASTROENTEROLOGY, 2016, 150 (04) : S211 - S211
[5] Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals
Bakshi, Andrew
Cao, Yin
Orchard, Suzanne G.
Carr, Prudence R.
Joshi, Amit D.
Manning, Alisa K.
Buchanan, Daniel D.
Umar, Asad
Winship, Ingrid M.
Gibbs, Peter
Zalcberg, John R.
Macrae, Finlay
McNeil, John J.
Lacaze, Paul
Chan, Andrew T.
[J]. CANCER PREVENTION RESEARCH, 2022, 15 (07) : 447 - 454
[6] Aspirin, NSAID, and acetaminophen use and the risk of endometrial cancer
Viswanathan, Akila N.
Feskanich, Diane
Schernhammer, Eva S.
Hankinson, Susan E.
[J]. CANCER RESEARCH, 2008, 68 (07) : 2507 - 2513
[7] Association of genetic variants of human telomerase with colorectal polyps and colorectal cancer risk
Hofer, Philipp
Baierl, Andreas
Bernhart, Kathrin
Leeb, Gernot
Mach, Karl
Micksche, Michael
Gsur, Andrea
[J]. MOLECULAR CARCINOGENESIS, 2012, 51 : E176 - E182
[8] The influence of NSAID use on colorectal cancer risk
[J]. Nature Clinical Practice Gastroenterology & Hepatology, 2006, 3 (9): : 479 - 480
[9] Aspirin use and the risk of colorectal cancer according to cyclooxygenase-2 expression
Chan, Andrew T.
Ogino, Shoji
Fuchs, Charles S.
[J]. GASTROENTEROLOGY, 2007, 132 (04) : A23 - A23
[10] Evaluation of genetic variants in association with colorectal cancer risk and survival in Asians
Wang, Nan
Lu, Yingchang
Khankari, Nikhil K.
Long, Jirong
Li, Hong-Lan
Gao, Jing
Gao, Yu-Tang
Xiang, Yong-Bing
Shu, Xiao-Ou
Zheng, Wei
[J]. INTERNATIONAL JOURNAL OF CANCER, 2017, 141 (06) : 1130 - 1139

← 1 2 3 4 5 →