Safety and immunogenicity of single dose of tetanus-diphtheria (Td) vaccine among non/partially immune children against diphtheria and/or tetanus, Hyderabad, India, 2007

被引：4
|
作者：
Bitragunta, Sailaja [2 ]
Murhekar, Manoj V. [1 ]
Chakravarti, Anita [3 ]
Verma, Vikas [3 ]
Namjoshi, Gajanan S. [4 ]
Parekh, Sameer S. [4 ]
Sharma, Hitt J. [4 ]
Kumar, B. Kishore [4 ]
Gupte, Mohan D. [4 ]
机构：
[1] Indian Council Med Res, Natl Inst Epidemiol, Tamil Nadu Housing Board, Madras 600070, Tamil Nadu, India
[2] Govt Andhra Pradesh, Directorate Hlth Serv, Hyderabad, Andhra Pradesh, India
[3] Maulana Azad Med Coll, Dept Microbiol, New Delhi, India
[4] Serum Inst India Ltd, Med Affairs Dept, Pune, Maharashtra, India
来源：
VACCINE | 2010年 / 28卷 / 37期
关键词：
Tetanus; Diphtheria; Vaccine; Immunogenicity; India;
D O I：
10.1016/j.vaccine.2010.06.047
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In Hyderabad, India, diphtheria is common among children aged 5-19 years. On account of low coverage of diphtheria vaccine boosters recommended under the universal immunization programme, a large proportion of children were susceptible/partially immune against diphtheria and/or tetanus. We evaluated immunogenicity and safety of single dose of indigenously developed tetanus-diphtheria (Td) vaccine (diphtheria-toxoid <= 5 LF) among 483 school children from Hyderabad aged 7-17 years and susceptible/partially immune against diphtheria and/or tetanus. Serological testing 6 weeks after vaccination indicated that vaccine was highly immunogenic with >96% sero-protected against both antigens. The immune response observed indicated a booster response to previously acquired immunity. Administration of additional dose of Td vaccine to the older school children and replacing the tetanus toxoid vaccine with Td in the school health programme would considerably reduce diphtheria burden in Hyderabad. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5934 / 5938
页数：5
相关论文
共 50 条
  • [1] Safety and immunogenicity of a new equine tetanus immunoglobulin associated with tetanus-diphtheria vaccine
    Lang, J
    Kamga-Fotso, L
    Peyrieux, JC
    Blondeau, C
    Lutsch, C
    Forrat, R
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2000, 63 (5-6): : 298 - 305
  • [2] Safety and immunogenicity of a single intramuscular dose of a tetanus-diphtheria toxoid (Td) vaccine (BR-TD-1001) in healthy Korean adult subjects
    Hong, Taegon
    Chung, Yong-Ju
    Kim, Tae-Yeon
    Kim, Ik-Hwan
    Choe, Yong-Kyung
    Lee, Jongtae
    Jeon, Sangil
    Han, Seunghoon
    Yim, Dong-Seok
    [J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2015, 11 (10) : 2440 - 2445
  • [3] Immunogenicity and reactogenicity of a single dose of a diphtheria-tetanus-acellular pertussis component vaccine (DTaP) compared to a diphtheria-tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults
    Bartels, I
    Jüngert, J
    Lugauer, S
    Stehr, K
    Heininger, U
    [J]. VACCINE, 2001, 19 (23-24) : 3137 - 3145
  • [4] Immunization coverage and immunity to diphtheria and tetanus among children in Hyderabad, India
    Murhekar, Manoj V.
    Bitragunta, Sailaja
    Hutin, Yvan
    Ckakravarty, Anita
    Sharma, Hitt J.
    Gupte, Mohan D.
    [J]. JOURNAL OF INFECTION, 2009, 58 (03) : 191 - 196
  • [5] Effect of tetanus-diphtheria (Td) vaccine on immune response to hepatitis B vaccine in healthy individuals with insufficient immune response
    Salehi, Maryam
    Haghighat, Abbas
    Salehi, Hassan
    Taleban, Roya
    Salehi, Marzieh
    Kalbasi, Nader
    Moafi, Mohammad
    Salehi, Mohammad Mahdi
    [J]. JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 2015, 20 (10): : 958 - 962
  • [6] Immunogenicity and safety of a single intramuscular dose of a diphtheria-tetanus toxoid (Td) vaccine (GC1107) in Korean adults
    Lee, SeungHwan
    Park, Wan Beom
    Shin, Kwang-Hee
    Ahn, Dong Ho
    Yoon, Seo Hyun
    Cho, Joo-Youn
    Shin, Sang-Goo
    Jang, In-Jin
    Yu, Kyung-Sang
    [J]. VACCINE, 2011, 29 (44) : 7638 - 7643
  • [7] IMMUNOGENICITY AND SAFETY OF A SINGLE INTRAMUSCULAR DOSE OF A DIPHTHERIA-TETANUS TOXOID (TD) VACCINE (GC1107) IN KOREAN ADULTS
    Lee, S.
    Shin, K.
    Shin, D.
    Yoon, S.
    Cho, J.
    Yu, K.
    Shin, S.
    Jang, I.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 : S58 - S58
  • [8] Immunogenicity of tetanus-diphtheria toxoids (Td) among Ukrainian adults: Implications for diphtheria control in the newly independent states of the former Soviet Union
    Sutter, RW
    Hardy, IR
    Kozlova, IA
    Tchoudnaia, LM
    Gluskevich, TG
    Marievsky, V
    Deforest, A
    Wharton, M
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 : S197 - S202
  • [9] The immunogenicity and safety of a new combined diphtheria, tetanus and poliomyelitis booster vaccine (Td-eIPV)
    P. Laroche
    M. Barrand
    S. C. Wood
    K. Van Hasbrouck
    J. Lang
    E. Harzer
    L. Hessel
    [J]. Infection, 1999, 27 : 49 - 56
  • [10] The immunogenicity and safety of a new combined diphtheria, tetanus and poliomyelitis booster vaccine (Td-eIPV)
    Laroche, P
    Barrand, M
    Wood, SC
    Van Hasbrouck, K
    Lang, J
    Harzer, E
    Hessel, L
    [J]. INFECTION, 1999, 27 (01) : 49 - 56
12345