A role for brain-derived neurotrophic factor in B cell development

被引：72
|
作者：
Schuhmann, B
Dietrich, A
Sel, S
Hahn, C
Klingenspor, M
Lommatzsch, M
Gudermann, T
Braun, A
Renz, H
Nockher, WA
机构：
[1] Univ Marburg, Dept Clin Chem & Mol Diagnost, Univ Hosp, D-35033 Marburg, Germany
[2] Univ Marburg, Inst Pharmacol & Toxicol, D-35033 Marburg, Germany
[3] Univ Marburg, Dept Biol, D-35033 Marburg, Germany
[4] Univ Med Clin, Dept Pneumol, D-18055 Rostock, Germany
[5] Fraunhofer Inst Toxicol & Expt Med, Dept Immunol & Allergol, D-30625 Hannover, Germany
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 163卷 / 1-2期
关键词：
neurotrophins; brain-derived neurotrophic factor; hematopoesis; bone marrow stromal cells; neuroimmunology;
D O I：
10.1016/j.jneuroim.2005.01.023
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75(NTR) and TrkB(gp95), while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+](i) in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：15 / 23
页数：9
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