Association between chronic kidney disease and Alzheimer's disease: an update

被引：47

作者：

Zhang, Chun-Yun ^{[1
]}

He, Fang-Fang ^{[1
]}

Su, Hua ^{[1
]}

Zhang, Chun ^{[1
]}

Meng, Xian-Fang ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Nephrol, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Neurobiol, Tongji Med Coll, Wuhan 430030, Peoples R China

来源：

METABOLIC BRAIN DISEASE | 2020年 / 35卷 / 06期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Alzheimer's disease; Chronic kidney disease; Cognitive impairment; CALCIUM-CHANNEL BLOCKADE; AMYLOID BETA-PROTEIN; VITAMIN-D; MOUSE MODEL; COGNITIVE IMPAIRMENT; CONVERTING ENZYME; A-BETA; PARATHYROID-HORMONE; OXIDATIVE STRESS; INDOXYL SULFATE;

D O I：

10.1007/s11011-020-00561-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been accepted that kidney function is connected with brain activity. In clinical studies, chronic kidney disease (CKD) patients have been found to be prone to suffering cognitive decline and Alzheimer's disease (AD). The cognitive function of CKD patients may improve after kidney transplantation. All these indicators show a possible link between kidney function and dementia. However, little is known about the mechanism behind the relation of CKD and AD. This review discusses the associations between CKD and AD from the perspective of the pathophysiology of the kidney and complications and/or concomitants of CKD that may lead to cognitive decline in the progression of CKD and AD. Potential preventive and therapeutic strategies for AD are also presented. Further studies are warranted in order to confirm whether the setting of CKD is a possible new determinant for cognitive impairment in AD.

引用

页码：883 / 894

页数：12

共 50 条

[1] Association between chronic kidney disease and Alzheimer’s disease: an update
Chun-Yun Zhang
Fang-Fang He
Hua Su
Chun Zhang
Xian-Fang Meng
Metabolic Brain Disease, 2020, 35 : 883 - 894
[2] The association between chronic kidney disease and cardiovascular disease
Orias, Marcelo
REVISTA DE LA FEDERACION ARGENTINA DE CARDIOLOGIA, 2011, 40 (04): : 311 - 312
[3] Systematic review of the association between Alzheimer's disease and chronic glaucoma
Tsilis, Alexandros G.
Tsilidis, Konstantinos K.
Pelidou, Sygkliti-Henrietta
Kitsos, George
CLINICAL OPHTHALMOLOGY, 2014, 8 : 2095 - 2104
[4] Systematic review of the association between Alzheimer's disease and chronic glaucoma
Janssen, Sarah F.
Jansonius, Nomdo M.
Bouwman, Femke
Verbraak, Frank D.
Bergen, Arthur A.
CLINICAL OPHTHALMOLOGY, 2015, 9 : 783 - +
[5] Alzheimer's disease and chronic periodontitis: Is there an association?
Gaur, Sumit
Agnihotri, Rupali
GERIATRICS & GERONTOLOGY INTERNATIONAL, 2015, 15 (04) : 391 - 404
[6] Association between periodontitis and chronic kidney disease
Parsegian, Karo
Randall, David
Curtis, Mike
Ioannidou, Effie
PERIODONTOLOGY 2000, 2022, 89 (01) : 114 - 124
[7] ASSOCIATION BETWEEN PREECLAMPSIA AND CHRONIC KIDNEY DISEASE
Villarreal Rios, Enrique
Lopez Bejarano, Paulina Itzel
Galicia Rodriguez, Liliana
Vargas Daza, Emma Rosa
Martinez Gonzalez, Lidia
Lugo Rodriguez, Ariosto
REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE, 2019, 39 (03): : 184 - 191
[8] Association between treatment with sacubitril/valsartan and the risk of Alzheimer's disease: a clinical update
Garnier-Crussard, Antoine
ALZHEIMERS RESEARCH & THERAPY, 2024, 16 (01)
[9] Association between alcohol and Alzheimer's disease
Huang, Wen-Juan
Zhang, Xia
Chen, Wei-Wei
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (03) : 1247 - 1250
[10] Association between Periodontitis and Alzheimer's Disease
Abbayya, Keshava
Puthanakar, Nagraj Y.
Naduwinmani, Sanjay
Chidambar, Y. S.
NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES, 2015, 7 (06) : 241 - 246

← 1 2 3 4 5 →