Endocrine side-effects of new anticancer therapies: Overall monitoring and conclusions

被引：24

作者：

Castinetti, Frederic ^{[1
]}

Albarel, Frederic ^{[1
]}

Archambeaud, Francoise ^{[2
]}

Bertherat, Jerome ^{[3
]}

Bouillet, Benjamin ^{[4
,5
]}

Buffier, Perrine ^{[4
]}

Briet, Claire ^{[6
]}

Cariou, Bertrand ^{[7
]}

Caron, Philippe ^{[8
]}

Chabre, Olivier ^{[9
]}

Chanson, Philippe ^{[10
]}

Cortet, Christine ^{[11
]}

Do Cao, Christine ^{[11
]}

Drui, Delphine ^{[7
]}

Haissaguerre, Magali ^{[12
]}

Hescot, Segolene ^{[13
]}

Illouz, Frederic ^{[14
]}

Kuhn, Emmanuelle ^{[10
]}

Lahlou, Najiba ^{[15
]}

Merlen, Emilie ^{[11
]}

Raverot, Veronique ^{[16
]}

Smati, Sarra ^{[7
]}

Verges, Bruno ^{[4
,5
]}

Borson-Chazot, Francoise ^{[17
]}

机构：

[1] Aix Marseille Univ, Hop Concept, AP HM, Dept Endocrinol,MMG,INSERM,U1251,Ctr Reference Ma, F-13005 Marseille, France

[2] Serv Med Interne B, Endocrinol, F-87042 Limoges, France

[3] Hop Cochin, Serv Endocrinol & Malad Metab, F-75674 Paris 14, France

[4] CHU Dijon, Hop Francois Mitterrand, Serv Endocrinol Diabetol Malad Metab, F-21034 Dijon, France

[5] Univ Bourgogne, Unite Inserm LNC UMR 1231, F-21000 Dijon, France

[6] Angers Univ, Univ Med Ctr, Inst MITOVASC, Inserm,Dept Endocrinol Diabetol & Nutr,U1083, F-49000 Angers, France

[7] CHU Nantes, Inst Thorax, Dept Endocrinol, F-44000 Nantes, France

[8] CHU Toulouse, Hop Larrey, Serv Endocrinol Malad Metab Nutr, TSA 30030, F-30030 Toulouse 9, France

[9] CHU Grenoble, Hop Albert Michallon, Serv Endocrinol Diabetol Nutr, F-38043 Grenoble 9, France

[10] Univ Paris Saclay, Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod,UMR S 1185,Fac Med, F-94275 Le Kremlin Bicetre, France

[11] CHRU Lille, Hop Huriez, Serv Endocrinol, F-59037 Lille, France

[12] CHU Bordeaux, Hop Haut Leveque, Serv Endocrinol Diabetol & Malad Metab, F-33604 Pessac, France

[13] Inst Curie, Oncol Endocrinienne, F-92210 St Cloud, France

[14] Hosp Angers, Reference Ctr Rare Thyroid Dis, Dept Endocrinol Diabet & Nutr, F-49933 Angers 09, France

[15] BPR AS, Dept Hormonol Specialisee, F-45700 Pannes, France

[16] Hosp Civils Lyon, Grp Hosp Est, Serv Biochim & Biol Mol, Lab Hormonol, F-69008 Lyon, France

[17] Univ Claude Bernard Lyon 1, Hosp Civils Lyon, HESPER EA 7425, Federat Endocrinol, F-69008 Lyon, France

来源：

ANNALES D ENDOCRINOLOGIE | 2018年 / 79卷 / 05期

关键词：

Immunotherapy; Tyrosine kinase inhibitors; MTOR inhibitors; Dysthyroidism; Hypophysitis; Diabetes; Dyslipidemia; Adrenal failure;

D O I：

10.1016/j.ando.2018.07.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present final consensus statement of the French Society of Endocrinology lays out the assessments that are to be systematically performed before and during anticancer treatment by immunotherapy, tyrosine kinase inhibitors or mTOR inhibitors, even without onset of any endocrinopathy. It also discusses the CTCAE adverse event grading system in oncology and the difficulty of implementing it for endocrine side-effects of these anticancer treatments. Notably, this is why certain treatment steps applied in other side-effects (e.g., high-dose corticosteroids, contraindications to immunotherapy, etc.) need to be discussed before implementation for endocrine side-effects. (C) 2018 Elsevier Masson SAS. All rights reserved.

引用

页码：591 / 595

页数：5

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