Breakthrough infection of Trichosporon asahii during posaconazole treatment in a patient with acute myeloid leukaemia

被引：23
|
作者：
Rieger, C. [1 ]
Geiger, S. [1 ]
Herold, T. [1 ]
Nickenig, C. [1 ]
Ostermann, H. [1 ]
机构：
[1] Univ Munich, Univ Hosp Grosshadern, Dept Hematol & Oncol, D-81377 Munich, Germany
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2007年 / 26卷 / 11期
关键词：
trichosporon; posaconazole; breakthrough infection; acute myeloid leukaemia;
D O I：
10.1007/s10096-007-0366-5
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A neutropenic patient with acute myeloid leukaemia experienced a breakthrough infection of Trichosporon asahii during posaconazole treatment. After treatment was changed to a combination therapy with voriconazole and liposomal amphotericin B, the infection resolved. Posaconazole works effectively as an antifungal prophylaxis and salvage therapy in rare invasive fungal infections. This case however illustrates that breakthrough infections with T. asahii may occur during posaconazole treatment.
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页码：843 / 845
页数：3
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