Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells

被引：0
|
作者：
Fraifeld, V
Seidman, R
Sagi, O
Muradian, K
Wolfson, M
机构：
[1] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Pharmacol, IL-84105 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, Ctr Multidisciplinary Res Aging, IL-84105 Beer Sheva, Israel
[3] Ukraine Acad Med Sci, Inst Gerontol, Physiol Lab, UA-252655 Kiev, Ukraine
来源：
ANTICANCER RESEARCH | 2001年 / 21卷 / 3B期
关键词：
aurintricarboxylic acid; SKOV3 and MCF7 human carcinoma cells; cell growth; colony formation;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of aurintricarboxylic acid (ATA) on cell growth and proliferative capacity was studied in human ovarian SKOV3 and breast MCF7 carcinoma cells. ATA moderately inhibited cell growth measured by a Neutral red assay after a 24-hour incubation of the cells in the presence of ATA. The ATA-treated cells displayed a markedly decreased capacity to proliferate, as was evident from a colony formation assay. The initial and delayed anti proliferative effects of ATA were dose-dependent. Together, the results indicated that ATA offers the potential of being recognized as an anti-tumor drug, at least in certain types of cancers.
引用
收藏
页码：1975 / 1978
页数：4
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