Maternal opioid use is reflected on leukocyte telomere length of male newborns

被引:5
|
作者
Abad, Fatemeh Rahimi Mehdi [1 ]
Khalili, Parvin [2 ,3 ]
Jalali, Fatemeh [4 ,5 ]
Pirsadeghi, Ali [6 ]
Nadimi, Ali Esmaeili [5 ,7 ]
Manshoori, Azita [8 ]
Jalali, Zahra [1 ,5 ]
机构
[1] Rafsanjan Univ Med Sci, Sch Med, Dept Clin Biochem, Rafsanjan, Iran
[2] Rafsanjan Univ Med Sci, Social Determinants Hlth Res Ctr, Rafsanjan, Iran
[3] Iran Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran
[4] Rafsanjan Univ Med Sci, Sch Med, Dept Pediat, Rafsanjan, Iran
[5] Rafsanjan Univ Med Sci, Noncommunicable Dis Res Ctr, Rafsanjan, Iran
[6] Rafsanjan Univ Med Sci, Mol Med Res Ctr, Res Inst Basic Med Sci, Rafsanjan, Iran
[7] Rafsanjani Univ Med Sci, Sch Med, Dept Cardiol, Rafsanjan, Iran
[8] Rafsanjan Univ Med Sci, Sch Med, Dept Gynecol, Rafsanjan, Iran
来源
PLOS ONE | 2021年 / 16卷 / 12期
关键词
REPORTED DRUG-USE; LOW-BIRTH-WEIGHT; DNA METHYLATION; VALIDITY; SHORTER; SMOKING; AGE; PREGNANCIES; WOMEN;
D O I
10.1371/journal.pone.0261013
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Opioid use accelerates normal aging in adults that raises a question on whether it may trans-generationally affect aging and aging biomarkers in the offspring of users as well? In the present research, we investigated the relative telomere length in umbilical cord blood of newborns born to opioid consuming mothers compared to normal controls. Telomere length shortening is a known biomarker of aging and aging related diseases. Its measure at birth or early in life is considered as a predictor of individual health in adulthood. Here, we performed a case-control study to investigate whether maternal opioid use affects newborns relative telomere length (RTL). 57 mother-newborn dyads were included in this study, 30 neonates with opioid using mothers (OM), and 27 with not-opioid using mothers (NOM)). RTL was measured in leukocyte cells genomic DNA using real-time PCR. The correlation of maternal opioid use with neonates telomer length was assessed using logistic regression analysis. The results displayed a significant association between odds ratio of long RTL and maternal opioid use when sensitivity analysis was performed by neonate sex; where the data indicates significantly increased odds ratio of long leukocyte RTL in association with maternal opioid use in male neonates only. Further work is necessary to assess this association in larger samples and test the potential underlying mechanisms for this observation.
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页数:15
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