Marker rescue mapping of the combined Condit/Dales collection of temperature-sensitive vaccinia virus mutants

被引：24
|
作者：
Kato, Sayuri E. M. [1 ]
Moussatche, Nissin [1 ,2 ]
D'Costa, Susan M. [1 ]
Bainbridge, Travis W. [1 ]
Prins, Cindy [1 ]
Strahl, Audra L. [1 ]
Shatzer, Amber N. [1 ]
Brinker, Alyson J. [1 ]
Kay, Nicole E. [1 ]
Condit, Richard C. [1 ]
机构：
[1] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA
[2] Univ Fed Rio de Janeiro, CCS, Inst Biofis Carlos Chagas Filho, Lab Biol Mol Virus, BR-21941902 Rio de Janeiro, RJ, Brazil
来源：
VIROLOGY | 2008年 / 375卷 / 01期
关键词：
vaccinia virus; temperature sensitive mutant; genetics; poxvirus; mapping;
D O I：
10.1016/j.virol.2008.01.027
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Complementation analysis of the combined Condit/Dales collection of vaccinia virus temperature-sensitive mutants has been reported (Lackner, C.A., D'Costa, S.M., Buck, C., Condit, R.C., 2003. Complementation analysis of the Dales collection of vaccinia virus temperature-sensitive mutants. Virology 305, 240-259), however not all complementation groups have previously been assigned to single genes on the viral genome. We have used marker rescue to map at least one representative of each complementation group to a unique viral gene. The final combined collection contains 124 temperature-sensitive mutants affecting 38 viral genes, plus five double mutants. (c) 2008 Elsevier Inc. All rights reserved.
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页码：213 / 222
页数：10
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