Role of angiotensin receptor blockers in patients with left ventricular dysfunction: lessons from CHARM and VALIANT

被引：8
|
作者：
Voors, AA [1 ]
van Veldhuisen, DJ [1 ]
机构：
[1] Univ Groningen Hosp, Thoraxctr, Dept Cardiol, NL-9700 RB Groningen, Netherlands
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2004年 / 97卷 / 03期
关键词：
angiotensin receptor blockers; left ventricular dysfunction; CHARM; VALIANT;
D O I：
10.1016/j.ijcard.2004.03.062
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The role of angiotensin receptor blockers (ARBs) in patients with left ventricular dysfunction has changed after the VALIANT and CHARM trials. CHARM proved that candesartan is a good alternative for patients with chronic heart failure who cannot tolerate ACE-inhibitors. Moreover, VALIANT demonstrated non-inferiority of valsartan compared to captopril in patients after an acute myocardial infarction. The add-on effects of an ARB on top of an ACE-inhibitor are somewhat less pronounced, although a reduction in the number of hospitalizations for heart failure seems a consistent finding. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：345 / 348
页数：4
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