Carbon ion radiotherapy for stage I non-small cell lung cancer

被引:164
|
作者
Miyamoto, T
Yamamoto, N
Nishimura, H
Koto, M
Tsujii, H
Mizoe, J
Kamada, T
Kato, H
Yamada, S
Morita, S
Yoshikawa, K
Kandatsu, S
Fujisawa, T
机构
[1] Natl Inst Radiol Sci, Res Ctr Hosp Charged Particle Therapy, Inage Ku, Chiba 2638555, Japan
[2] Chiba Univ, Grad Sch Med, Dept Thorac Surg, Chiba, Japan
关键词
carbon beam; stage I non-small cell lung cancer; phase I/II; radical radiotherapy;
D O I
10.1016/S0167-8140(02)00367-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and purpose: Heavy ion radiotherapy is a promising modality because of its excellent dose localization and high biological effect on tumors. Using carbon beams, a dose escalation study was conducted for the treatment of stage I non-small cell lung cancer (NSCLC) to determine the optimal dose. Materials and methods: The first stage phase I/II trial using 18 fractions over 6 weeks for 47 patients and the second one using nine fractions over 3 weeks for 34 patients were conducted by the dose escalation method from 59.4 to 95.4 Gray equivalents (GyE) in incremental steps of 10% and from 68.4 to 79.2 GyE in 5% increments, respectively. The local control and survival rates were obtained using the Kaplan-Meier method. Results: Radiation pneumonitis at grade III occurred in three of 81 patients, but they fully recovered. This was not a dose-limiting factor. The local control rates in the first and second trials were 64% and 84%, respectively. The total recurrence rate in both trials was 23.2%. The infield local recurrence in the first trial was significantly dependent on carbon dose. The doses greater than 86.4 GyE at 18 fractions and 72 GyE at nine fractions achieved a local control of 90% and 95%, respectively. The 5 year overall and cause-specific survivals in 81 patients were 42% and 60%, respectively. Conclusions: With our dose escalation study, the optimum safety and efficacy dose of carbon beams was determined. Carbon beam therapy attained almost the same results as surgery for stage I NSCLC although this was a I/II study. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:127 / 140
页数:14
相关论文
共 50 条
  • [1] Carbon ion radiotherapy in hypofraction regimen for stage I non-small cell lung cancer
    Miyamoto, T.
    Baba, M.
    Kagei, K.
    Yashiro, T.
    Hirasawa, N.
    Tujii, H.
    PROCEEDINGS OF THE 10TH CENTRAL EUROPEAN LUNG CANCER CONFERENCE, 2006, : 61 - +
  • [2] Carbon ion radiotherapy in hypofraction regimen for stage I non-small cell lung cancer
    Miyamoto, T.
    Baba, M.
    Yashiro, T.
    Kagei, K.
    Tujii, H.
    Fujisawa, T.
    LUNG CANCER, 2006, 52 : S26 - S26
  • [3] Modeling of the resensitization effect on carbon-ion radiotherapy for stage I non-small cell lung cancer
    Inaniwa, Taku
    Kanematsu, Nobuyuki
    Nakajima, Mio
    PHYSICS IN MEDICINE AND BIOLOGY, 2024, 69 (10):
  • [4] Local control and recurrence of stage I non-small cell lung cancer after carbon ion radiotherapy
    Koto, M
    Miyamoto, T
    Yamamoto, N
    Nishimura, H
    Yamada, S
    Tsujii, H
    RADIOTHERAPY AND ONCOLOGY, 2004, 71 (02) : 147 - 156
  • [5] Stereotactic radiotherapy in stage I non-small cell lung cancer
    Fleckenstein, J.
    Ruebe, C.
    ONKOLOGE, 2018, 24 (12): : 967 - 973
  • [6] Value of carbon-ion radiotherapy for early stage non-small cell lung cancer
    Ruan, Hanguang
    Xiong, Juan
    CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY, 2022, 36 : 16 - 23
  • [7] A PRELIMINARY REPORT OF SINGLE FRACTION CARBON-ION RADIOTHERAPY FOR STAGE I NON-SMALL CELL LUNG CANCER
    Baba, M.
    Sugane, T.
    Nakajima, M.
    Yamamoto, N.
    Miyamoto, T. A.
    Kandatsu, S.
    Yoshikawa, K.
    Matsufuji, N.
    Minohara, S. I.
    Kamada, T.
    Mizoe, J. E.
    Tsujii, H.
    RADIOTHERAPY AND ONCOLOGY, 2008, 88 : S275 - S276
  • [8] Carbon ion radiotherapy for elderly patients 80 years and older with stage I non-small cell lung cancer
    Sugane, Toshio
    Baba, Masayuki
    Imai, Reiko
    Nakajima, Mio
    Yamamoto, Naoyoshi
    Miyamoto, Tadaaki
    Ezawa, Hidefumi
    Yoshikawa, Kyousan
    Kandatsu, Susumu
    Kamada, Tadashi
    Mizoe, Junetsu
    Tsujii, Hirohiko
    LUNG CANCER, 2009, 64 (01) : 45 - 50
  • [9] Carbon ion radiotherapy for stage I non-small cell lung cancer: A Meta-analysis of 369 patients
    Zhang, Q.
    Tian, J.
    Wang, X.
    RADIOTHERAPY AND ONCOLOGY, 2016, 119 : S585 - S585
  • [10] Efficacy and Safety of Carbon-Ion Radiotherapy for Stage I Non-Small Cell Lung Cancer with Coexisting Interstitial Lung Disease
    Okano, Naoko
    Kubo, Nobuteru
    Yamaguchi, Koichi
    Kouno, Shunichi
    Miyasaka, Yuhei
    Mizukami, Tatsuji
    Shirai, Katsuyuki
    Saitoh, Jun-ichi
    Ebara, Takeshi
    Kawamura, Hidemasa
    Maeno, Toshitaka
    Ohno, Tatsuya
    CANCERS, 2021, 13 (16)