A radical cyclization approach to the formal total syntheses of platencin

被引：28

作者：

Palanichamy, Kalanidhi ^{[1
]}

Subrahmanyam, Ayyagari V. ^{[1
]}

Kaliappan, Krishna P. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 22期

关键词：

ACTIVATED DIMETHYL-SULFOXIDE; HYDROXYL GROUP; ANTIBACTERIAL PROPERTIES; ENANTIOSELECTIVE ROUTE; OXATETRACYCLIC CORE; CARBONYL-COMPOUNDS; PLATENSIMYCIN; ANALOGS; FABF; (-)-PLATENSIMYCIN;

D O I：

10.1039/c1ob06155k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two different strategies leading to formal total syntheses of platencin are described. The first strategy involving Claisen rearrangement and radical cyclization provides a rapid access to the core structure of platencin, and also use minimum protective-group operations. The second strategy, a protecting group-free route, utilizes a 6-exo-trig radical cyclization and aldol condensation as key steps leading to the formal synthesis of platencin.

引用

页码：7877 / 7886

页数：10

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