Anti-nociceptive effect of neuropeptide Y in periaqueductal grey in rats with inflammation

被引：22
|
作者：
Wang, JZ
Lundeberg, T
Yu, LC [1 ]
机构：
[1] Peking Univ, Coll Life Sci, Dept Physiol, Beijing 100871, Peoples R China
[2] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden
[3] Karolinska Inst, Dept Rehabil Med, S-17177 Stockholm, Sweden
来源：
BRAIN RESEARCH | 2001年 / 893卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
hindpaw withdrawal latency; inflammation; periaqueductal grey; neuropeptide Y; Y1; receptor;
D O I：
10.1016/S0006-8993(00)03279-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Experimental inflammation was induced by subcutaneous injection of carrageenan into the left hindpaw of rats. Intra-periaqueductal grey (PAG) injection of 0.02 or 0.1 nmol of neuropeptide Y (NPY), but not 0.004 nmol, induced significant increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with inflammation. Furthermore, the anti-nociceptive effect of NPY was blocked partly by following intra-PAG injection of the Y1 receptor antagonist NPY28-36. The results demonstrated that NPY plays an anti-nociceptive role in PAG in rats with inflammation, in which Y1 receptor is involved. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：264 / 267
页数：4
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