Inhibitory effect of dietary wheat bran on formation of aberrant crypt foci in rat colon induced by a single injection of 1,2-dimethylhydrazine

被引：18

作者：

Ishizuka, S

Kasai, T

机构：

[1] Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, 060, Kita-9, Nishi-9, Kita-ku

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 12期

关键词：

aberrant crypt foci; 1,2-dimethylhydrazine; wheat bran; rat;

D O I：

10.1271/bbb.60.2084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The frequency of appearance of aberrant crypt foci (ACF) in the distal colon was significantly lower in rats fed a high fiber (20% wheat bran) diet than in those fed a fiber-free one at 4 weeks after a single injection of 1,2-dimethylhydrazine (DMH, 20 mg/kg), although crypt/ACF was high in the former relative to the latter, This result suggests that dietary wheat bran effectively serves as a regulator of ACF frequency at early stages after DMH injection.

引用

页码：2084 / 2085

页数：2

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