Schizophrenia-spectrum risk alleles may persist in the population, despite their reproductive costs in individuals with schizophrenia, through the possible creativity benefits of mild schizotypy in non-psychotic relatives. To assess this creativity-benefit model, we measured creativity (using 6 verbal and 8 drawing tasks), schizotypy, Big Five personality traits, and general intelligence in 225 University of New Mexico students. Multiple regression analyses showed that openness and intelligence, but not schizotypy, predicted reliable observer ratings of verbal and drawing creativity. Thus, the 'madness-creativity' link seems mediated by the personality trait of openness, and standard creativity-benefit models seem unlikely to explain schizophrenia's evolutionary persistence. (c) 2007 Published by Elsevier B.V.