Regioselective removal of the anomeric O-benzyl from differentially protected carbohydrates

被引：13
|
作者：
Jalsa, Nigel Kevin [1 ]
机构：
[1] Univ W Indies, Dept Chem, St Augustine, Trinidad Tobago
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 49期
关键词：
Catalytic transfer hydrogenation; Protecting groups; Carbohydrates; Benzyl; Anomeric position; CATALYTIC TRANSFER HYDROGENATION; EFFICIENT SYNTHESIS; AMMONIUM FORMATE; GLYCOSIDES; ACETALS; HYDROGENOLYSIS; ETHERS; GLYCOSYLATION; DEPROTECTION; OLIGOSACCHARIDES;
D O I：
10.1016/j.tetlet.2011.09.130
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild, regioselective deprotection of the anomeric O-benzyl from multi-functionally protected carbohydrates via catalytic transfer hydrogenation is described. The protocol is tolerant of O-benzyl and O-benzylidene protections at non-anomeric positions, groups which are normally labile under typical hydrogenolysis conditions. (C) 2011 Elsevier Ltd. All rights reserved.
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页码：6587 / 6590
页数：4
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