Cervicovaginal colposcopic lesions associated with 5 nonoxynol-9 vaginal spermicide formulations

被引:7
|
作者
Harwood, Bryna [1 ]
Meyn, Leslie A. [2 ]
Ballagh, Susan A. [3 ]
Raymond, Elizabeth G.
Archer, David F. [3 ]
Creinin, Mitchell D. [2 ]
机构
[1] Univ Illinois, Coll Med, Chicago, IL 60680 USA
[2] Univ Pittsburgh, Sch Med, Magee Womens Res Inst, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA
[3] E Virginia Med Sch, Norfolk, VA USA
关键词
colposcopy; vaginal spermicides; epithelial disruption; nonoxynol-9;
D O I
10.1016/j.ajog.2007.05.020
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population. STUDY DESIGN: This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions. RESULTS: One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% Cl, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% Cl, 0.1-0.6; P < .001). CONCLUSION: In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.
引用
收藏
页码:32.e1 / 32.e7
页数:7
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