Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells

被引：45
|
作者：
Han, Xiaoyun [1 ,2 ]
Sheng, Xiugui [1 ]
Jones, Hannah M. [2 ]
Jackson, Amanda L. [2 ]
Kilgore, Joshua [2 ]
Stine, Jessica E. [2 ]
Schointuch, Monica N. [2 ]
Zhou, Chunxiao [2 ,3 ]
Bae-Jump, Victoria L. [2 ,3 ]
机构：
[1] ShanDong Canc Hosp & Canc Inst, Dept Gynecol Oncol, Jinan 250117, Peoples R China
[2] Univ N Carolina, Div Gynecol Oncol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2015年 / 8卷
关键词：
Endometrial Cancer; LDH; Galloflavin; Glycolysis;
D O I：
10.1186/s13045-014-0097-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. The present study was aimed at evaluating the potential of a novel lactate dehydrogenase (LDH) inhibitor, Galloflavin, as a therapeutic agent for endometrial cancer. Our results revealed that Galloflavin effectively inhibited cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis.
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页数：4
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