Real-time polymerase chain reaction detection of Bordetella pertussis DNA in acellular pertussis vaccines

被引:7
|
作者
Tatti, Kathleen M. [1 ]
Slade, Barbara [1 ]
Patel, Manisha [1 ]
Messonnier, Nancy [1 ]
Jackson, Tiffany [1 ]
Kirkland, Kathryn B. [2 ]
Talbot, Elizabeth A. [2 ]
Tondella, M. Lucia [1 ]
机构
[1] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Meningitis & Vaccine Preventable Dis Branch, Atlanta, GA 30333 USA
[2] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA
关键词
B; pertussis; vaccines; real-time PCR; environmental contamination; Tdap;
D O I
10.1097/INF.0b013e31814689a4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Using 2 real-time polymerase chain reaction (PCR) assays for Bordetella pertussis, 2 of 5 acellular pertussis vaccines were found to contain B. pertussis DNA. Because residual DNA in vaccines can cause environmental contamination, the administration of acellular pertussis vaccines to patients should be physically separated from the collection of patients' specimens for testing of B. pertussis DNA by real-time PCR.
引用
收藏
页码:73 / 74
页数:2
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