ISG15 secretion exacerbates inflammation in SARS-CoV-2 infection

被引：30
|
作者：
Cao, Xuetao [1 ,2 ]
机构：
[1] Nankai Univ, Coll Life Sci, Tianjin, Peoples R China
[2] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing, Peoples R China
来源：
NATURE IMMUNOLOGY | 2021年 / 22卷 / 11期
关键词：
D O I：
10.1038/s41590-021-01056-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Conjugation of the ubiquitin-like protein ISG15 to targets (ISGylation) benefits antiviral defense. However, SARS-CoV-2 induces human macrophages to preferentially secrete ISG15 via its papain-like protease, and extracellular non-conjugated ISG15 acts as a cytokine to exacerbate SARS-CoV-2-triggered inflammation.
引用
收藏
页码：1360 / 1362
页数：3
相关论文
共 50 条
  • [1] ISG15 secretion exacerbates inflammation in SARS-CoV-2 infection
    Xuetao Cao
    Nature Immunology, 2021, 22 : 1360 - 1362
  • [2] Free ISG15 and Protein ISGylation Emerging in SARS-CoV-2 Infection
    Tecalco Cruz, Angeles C.
    CURRENT DRUG TARGETS, 2022, 23 (07) : 686 - 691
  • [3] ISG15: its roles in SARS-CoV-2 and other viral infections
    Sarkar, Lucky
    Liu, Guanqun
    Gack, Michaela U.
    TRENDS IN MICROBIOLOGY, 2023, 31 (12) : 1262 - 1275
  • [4] ISG15 is responsible for endothelial inflammation and vascular disfunction induced by Spike protein 1 of SARS-CoV-2
    Rios, Francisco
    Montezano, Augusto
    Camargo, Livia
    Lopes, Rheure
    Garcia, Ana
    Aranday-Cortes, Elihu
    Briones, Ana
    McLauchlan, John
    Touyz, Rhian
    HYPERTENSION, 2024, 81
  • [5] INFLAMMATION ASSOCIATED WITH SARS-COV-2 INFECTION
    Patel, Aisha
    Ramanathan, Pavithra
    JOURNAL OF INVESTIGATIVE MEDICINE, 2021, 69 (05) : 1117 - 1119
  • [6] IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation
    Sadhu, Srikanth
    Dalal, Rajdeep
    Dandotiya, Jyotsna
    Binayke, Akshay
    Singh, Virendra
    Tripathy, Manas Ranjan
    Das, Vinayaka
    Goswami, Sandeep
    Kumar, Shakti
    Rizvi, Zaigham Abbas
    Awasthi, Amit
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [7] IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation
    Srikanth Sadhu
    Rajdeep Dalal
    Jyotsna Dandotiya
    Akshay Binayke
    Virendra Singh
    Manas Ranjan Tripathy
    Vinayaka Das
    Sandeep Goswami
    Shakti Kumar
    Zaigham Abbas Rizvi
    Amit Awasthi
    Nature Communications, 14
  • [8] The alarmin IL-33 exacerbates pulmonary inflammation and immune dysfunction in SARS-CoV-2 infection
    Wang, Hui
    Hosakote, Yashoda M.
    Boor, Paul J.
    Yang, Jun
    Zhang, Yuanyi
    Yu, Xiaoying
    Gonzales, Casey
    Levine, Corri B.
    McLellan, Susan
    Cloutier, Nicole
    Xie, Xuping
    Shi, Pei-Yong
    Ren, Ping
    Hu, Haitao
    Sun, Keer
    Soong, Lynn
    Sun, Jiaren
    Liang, Yuejin
    ISCIENCE, 2024, 27 (06)
  • [9] SARS-CoV-2 infection exacerbates diaphragmatic eventration: A case report
    Xu, Tao
    Yu, Wanjun
    BIOMEDICAL REPORTS, 2024, 21 (05)
  • [10] How ISG15 combats viral infection
    Freitas, Brendan T.
    Scholte, Florine E. M.
    Bergeron, Eric
    Pegan, Scott D.
    VIRUS RESEARCH, 2020, 286
12345